Structural and Functional Dissection of the Heterocyclic Peptide Cytotoxin Streptolysin S

The human pathogen Streptococcus pyogenes secretes a highly cytolytic toxin known as streptolysin S (SLS). SLS is a key virulence determinant and responsible for the β-hemolytic phenotype of these bacteria. Despite over a century of research, the chemical structure of SLS remains unknown. Recent exp...

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Veröffentlicht in:	The Journal of biological chemistry 2009-05, Vol.284 (19), p.13004-13012
Hauptverfasser:	Mitchell, Douglas A., Lee, Shaun W., Pence, Morgan A., Markley, Andrew L., Limm, Joyce D., Nizet, Victor, Dixon, Jack E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Proteins - physiology Mice Molecular Sequence Data Oxazoles - metabolism Proline - metabolism Protein Processing, Post-Translational Protein Synthesis, Post-Translational Modification, and Degradation Sequence Homology, Amino Acid Streptococcus pyogenes Streptococcus pyogenes - chemistry Streptolysins - chemistry Streptolysins - genetics Streptolysins - metabolism Streptolysins - physiology Substrate Specificity Surface Plasmon Resonance Thiazoles - metabolism Virulence
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