Proto-oncogene FBI-1 Represses Transcription of p21CIP1 by Inhibition of Transcription Activation by p53 and Sp1

Aberrant transcriptional repression through chromatin remodeling and histone deacetylation has been postulated as the driving force for tumorigenesis. FBI-1 (formerly called Pokemon) is a member of the POK family of transcriptional repressors. Recently, FBI-1 was characterized as a critical oncogeni...

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Veröffentlicht in:	The Journal of biological chemistry 2009-05, Vol.284 (19), p.12633-12644
Hauptverfasser:	Choi, Won-Il, Jeon, Bu-Nam, Yun, Chae-Ok, Kim, Pyung-Hwan, Kim, Sung-Eun, Choi, Kang-Yell, Kim, Se Hoon, Hur, Man-Wook
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell Cycle Cell Proliferation Chromatin Immunoprecipitation Colony-Forming Units Assay Cyclin-Dependent Kinase Inhibitor p21 - antagonists & inhibitors Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism DNA-Binding Proteins - physiology Electrophoretic Mobility Shift Assay Flow Cytometry Gene Expression Regulation, Neoplastic HeLa Cells Humans Immunoprecipitation Mutagenesis, Site-Directed Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Promoter Regions, Genetic Proto-Oncogene Mas RNA, Small Interfering - pharmacology Sp1 Transcription Factor - genetics Transcription Factors - physiology Transcription, Chromatin, and Epigenetics Transcription, Genetic - drug effects Transcriptional Activation - drug effects Tumor Cells, Cultured Tumor Suppressor Protein p53 - genetics
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