Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction

Aims The mechanisms involved in hypoxic pulmonary vasoconstriction (HPV) are not yet fully defined. The aim of the study was to determine the role of protein kinase C ζ (PKCζ) and neutral sphingomyelinase (nSMase) in HPV. Methods and results Ceramide content was measured by immunocytochemistry and v...

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Veröffentlicht in:	Cardiovascular research 2009-05, Vol.82 (2), p.296-302
Hauptverfasser:	Cogolludo, Angel, Moreno, Laura, Frazziano, Giovanna, Moral-Sanz, Javier, Menendez, Carmen, Castañeda, Javier, González, Constancio, Villamor, Eduardo, Perez-Vizcaino, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Ceramides - metabolism Disease Models, Animal Hypoxia - physiopathology Hypoxic pulmonary vasoconstriction Male Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Neutral sphingomyelinase Original Patch-Clamp Techniques Protein Kinase C - physiology Protein kinase C ζ Pulmonary arteries Pulmonary Artery - cytology Pulmonary Artery - physiopathology Rats Rats, Wistar RNA, Messenger - metabolism Signal Transduction - physiology Sphingomyelin Phosphodiesterase - metabolism Sphingomyelin Phosphodiesterase - physiology Vasoconstriction - physiology
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