Susceptibility loci for murine HIV-associated nephropathy encode trans-regulators of podocyte gene expression

Multiple studies have linked podocyte gene variants to diverse sporadic nephropathies, including HIV-1-associated nephropathy (HIVAN). We previously used linkage analysis to identify a major HIVAN susceptibility locus in mouse, HIVAN1. We performed expression quantitative trait locus (eQTL) analysis...

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Veröffentlicht in:	The Journal of clinical investigation 2009-05, Vol.119 (5), p.1178-1188
Hauptverfasser:	Papeta, Natalia, Chan, Ka-Tak, Prakash, Sindhuri, Martino, Jeremiah, Kiryluk, Krzysztof, Ballard, David, Bruggeman, Leslie A, Frankel, Rachelle, Zheng, Zongyu, Klotman, Paul E, Zhao, Hongyu, D'Agati, Vivette D, Lifton, Richard P, Gharavi, Ali G
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS-Associated Nephropathy - etiology AIDS-Associated Nephropathy - genetics Animals Biomedical research Cell cycle Chromosomes - genetics Crosses, Genetic Diagnosis Drug therapy Gene expression Gene Expression - genetics Gene Expression Regulation - genetics Genetic aspects Genetic Linkage - genetics Genetic Predisposition to Disease - genetics Genotype & phenotype Glomerulonephritis Health aspects HIV (Viruses) HIV-1 - genetics Intracellular Signaling Peptides and Proteins - genetics Kidney - metabolism Kidney - pathology Membrane Proteins - genetics Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Transgenic Microfilament Proteins - genetics Mutation Nonmuscle Myosin Type IIA - genetics Phosphoinositide Phospholipase C - genetics Phylogeny Podocytes - metabolism Polymorphism, Single Nucleotide - genetics Quantitative Trait Loci - genetics Risk factors
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