Enhanced clonogenic survival induced by protein tyrosine phosphatase (PTP) inhibition after Cr(VI) exposure is mediated by c-Raf and Ras activity

Our recent studies showed that maintenance of protein tyrosine phosphorylation by PTP inhibition enhanced cell growth, clonogenic survival, and mutagenesis after a single low-level Cr(VI) exposure, thereby suggesting that tyrosine phosphorylation-dependent signaling may govern inappropriate survival...

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Veröffentlicht in:	Cellular signalling 2009-05, Vol.21 (5), p.727-736
Hauptverfasser:	Bae, Dongsoon, Camilli, Tura C., Ha, Ngoc-Tram, Ceryak, Susan
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzoquinones - pharmacology Cell Line Cell Survival Chromium - toxicity Clonogenic lethality Down-Regulation Extracellular Signal-Regulated MAP Kinases - metabolism Gene Knockdown Techniques Genotoxic stress Hexavalent chromium [Cr(VI)] Humans Indoles - pharmacology Lactams, Macrocyclic - pharmacology MAP Kinase Kinase Kinases - metabolism Phenols - pharmacology Protein Tyrosine Phosphatases - antagonists & inhibitors Protein Tyrosine Phosphatases - metabolism Proto-Oncogene Proteins c-raf - metabolism PTP inhibitor ras Proteins - metabolism Ras/Raf/Mek/Erk pathway RNA, Small Interfering - metabolism Signal Transduction Sodium orthovanadate
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