ECM Compliance Regulates Osteogenesis by Influencing MAPK Signaling Downstream of RhoA and ROCK

The compliance of the extracellular matrix (ECM) regulates osteogenic differentiation by modulating extracellular signal‐regulated kinase (ERK) activity. However, the molecular mechanism linking ECM compliance to the ERK‐mitogen‐activated protein kinase (MAPK) pathway remains unclear. Furthermore, R...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of bone and mineral research 2009-05, Vol.24 (5), p.886-898
Hauptverfasser:	Khatiwala, Chirag B, Kim, Peter D, Peyton, Shelly R, Putnam, Andrew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Animals Biological and medical sciences bone Bone Matrix - drug effects Bone Matrix - enzymology Calcification, Physiologic - drug effects Cell Adhesion - drug effects Cell Line Compliance - drug effects Core Binding Factor Alpha 1 Subunit - metabolism differentiation extracellular matrix Extracellular Matrix - drug effects Extracellular Matrix - enzymology extracellular signal‐regulated kinase mitogen‐activated protein kinase Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Hydrogels Integrin-Binding Sialoprotein MAP Kinase Signaling System - drug effects Mice Models, Biological Original Osteocalcin - genetics Osteocalcin - metabolism Osteogenesis - drug effects Osteogenesis - genetics Phosphorylation - drug effects Polyethylene Glycols Protein Kinase Inhibitors - pharmacology rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism RhoA rhoA GTP-Binding Protein - antagonists & inhibitors rhoA GTP-Binding Protein - metabolism Sialoglycoproteins - genetics Sialoglycoproteins - metabolism Skeleton and joints Vertebrates: osteoarticular system, musculoskeletal system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!