Shared genetic basis for obstructive sleep apnea and adiposity measures
Introduction: Obesity and obstructive sleep apnea each have a substantial genetic basis and commonly coexist in individuals. The degree to which the genetic underpinnings for these disorders overlap has not been previously quantified. Methods: A total of 1802 individuals from 310 families in the Cle...
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| description | Introduction: Obesity and obstructive sleep apnea each have a substantial genetic basis and commonly coexist in individuals. The degree to which the genetic underpinnings for these disorders overlap has not been previously quantified. Methods: A total of 1802 individuals from 310 families in the Cleveland Family Study underwent home sleep studies as well as standardized assessment of body mass index (BMI) and circumferences at the waist, hip and neck. In 713 participants with laboratory sleep studies, fasting blood samples were assayed for leptin, adiponectin and resistin. Variance component models were used to estimate heritability and genetic correlations. Results: The heritability of the apnea hypopnea index (AHI) was 0.370.04 and 0.330.07 for home and laboratory sleep studies, respectively. The genetic correlations between AHI and anthropomorphic adiposity measures ranged from 0.57 to 0.61, suggesting that obesity can explain nearly 40% of the genetic variance in sleep apnea. The magnitude of the genetic correlations between apnea severity and adipokine levels was substantially less than those with anthropomorphic measures, ranging from 0.11 to 0.46. After adjusting for BMI, no significant genetic correlation with apnea severity was observed for any of the other adiposity measures. Conclusions: Substantial but not complete overlap in genetic bases exists between sleep apnea and anthropomorphic indices of adiposity, and this overlap accounts for more than one-third of the genetic variance in apnea severity. These findings suggest that genetic polymorphisms exist that importantly influence sleep apnea susceptibility through both obesity-dependent and -independent pathways. |
| doi_str_mv | 10.1038/sj.ijo.0803803 |
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The degree to which the genetic underpinnings for these disorders overlap has not been previously quantified. Methods: A total of 1802 individuals from 310 families in the Cleveland Family Study underwent home sleep studies as well as standardized assessment of body mass index (BMI) and circumferences at the waist, hip and neck. In 713 participants with laboratory sleep studies, fasting blood samples were assayed for leptin, adiponectin and resistin. Variance component models were used to estimate heritability and genetic correlations. Results: The heritability of the apnea hypopnea index (AHI) was 0.370.04 and 0.330.07 for home and laboratory sleep studies, respectively. The genetic correlations between AHI and anthropomorphic adiposity measures ranged from 0.57 to 0.61, suggesting that obesity can explain nearly 40% of the genetic variance in sleep apnea. The magnitude of the genetic correlations between apnea severity and adipokine levels was substantially less than those with anthropomorphic measures, ranging from 0.11 to 0.46. After adjusting for BMI, no significant genetic correlation with apnea severity was observed for any of the other adiposity measures. Conclusions: Substantial but not complete overlap in genetic bases exists between sleep apnea and anthropomorphic indices of adiposity, and this overlap accounts for more than one-third of the genetic variance in apnea severity. These findings suggest that genetic polymorphisms exist that importantly influence sleep apnea susceptibility through both obesity-dependent and -independent pathways.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0803803</identifier><identifier>PMID: 18209735</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>abdominal fat ; adipokines ; Adipose tissues ; Adiposity - genetics ; Adult ; Anthropomorphism ; Biological and medical sciences ; Blood ; body composition ; Body Mass Index ; Care and treatment ; complications ; Critical care ; Diagnosis ; disease severity ; Epidemiologic Methods ; epidemiological studies ; Epidemiology ; Family studies ; Female ; Genetic aspects ; genetic correlation ; genetic polymorphism ; Genetic Predisposition to Disease - epidemiology ; Genetic variance ; genetic variation ; Genetics ; Genotype ; Health Promotion and Disease Prevention ; heritability ; hormone secretion ; Humans ; inheritance (genetics) ; Internal Medicine ; Laboratories ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Obesity - genetics ; obesity-related diseases ; original-article ; Phenotype ; Physiological aspects ; Pneumology ; Polysomnography - methods ; Public Health ; Respiratory system : syndromes and miscellaneous diseases ; risk assessment ; Risk factors ; Sleep apnea ; Sleep apnea syndromes ; Sleep Apnea, Obstructive - epidemiology ; Sleep Apnea, Obstructive - genetics ; Treatment Outcome ; Waist-Hip Ratio</subject><ispartof>International Journal of Obesity, 2008-05, Vol.32 (5), p.795-800</ispartof><rights>Springer Nature Limited 2008</rights><rights>2008 INIST-CNRS</rights><rights>COPYRIGHT 2008 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c726t-c6c7e66e8ac8d697d6bed17ebc24fd1b61cb31bf618413a30afdcd6286ad2ad53</citedby><cites>FETCH-LOGICAL-c726t-c6c7e66e8ac8d697d6bed17ebc24fd1b61cb31bf618413a30afdcd6286ad2ad53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20315998$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18209735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, S.R</creatorcontrib><creatorcontrib>Larkin, E.K</creatorcontrib><creatorcontrib>Redline, S</creatorcontrib><title>Shared genetic basis for obstructive sleep apnea and adiposity measures</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Introduction: Obesity and obstructive sleep apnea each have a substantial genetic basis and commonly coexist in individuals. The degree to which the genetic underpinnings for these disorders overlap has not been previously quantified. Methods: A total of 1802 individuals from 310 families in the Cleveland Family Study underwent home sleep studies as well as standardized assessment of body mass index (BMI) and circumferences at the waist, hip and neck. In 713 participants with laboratory sleep studies, fasting blood samples were assayed for leptin, adiponectin and resistin. Variance component models were used to estimate heritability and genetic correlations. Results: The heritability of the apnea hypopnea index (AHI) was 0.370.04 and 0.330.07 for home and laboratory sleep studies, respectively. The genetic correlations between AHI and anthropomorphic adiposity measures ranged from 0.57 to 0.61, suggesting that obesity can explain nearly 40% of the genetic variance in sleep apnea. The magnitude of the genetic correlations between apnea severity and adipokine levels was substantially less than those with anthropomorphic measures, ranging from 0.11 to 0.46. After adjusting for BMI, no significant genetic correlation with apnea severity was observed for any of the other adiposity measures. Conclusions: Substantial but not complete overlap in genetic bases exists between sleep apnea and anthropomorphic indices of adiposity, and this overlap accounts for more than one-third of the genetic variance in apnea severity. These findings suggest that genetic polymorphisms exist that importantly influence sleep apnea susceptibility through both obesity-dependent and -independent pathways.</description><subject>abdominal fat</subject><subject>adipokines</subject><subject>Adipose tissues</subject><subject>Adiposity - genetics</subject><subject>Adult</subject><subject>Anthropomorphism</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>body composition</subject><subject>Body Mass Index</subject><subject>Care and treatment</subject><subject>complications</subject><subject>Critical care</subject><subject>Diagnosis</subject><subject>disease severity</subject><subject>Epidemiologic Methods</subject><subject>epidemiological studies</subject><subject>Epidemiology</subject><subject>Family studies</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>genetic correlation</subject><subject>genetic polymorphism</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genetic variance</subject><subject>genetic variation</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Health Promotion and Disease Prevention</subject><subject>heritability</subject><subject>hormone secretion</subject><subject>Humans</subject><subject>inheritance (genetics)</subject><subject>Internal Medicine</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Obesity - genetics</subject><subject>obesity-related diseases</subject><subject>original-article</subject><subject>Phenotype</subject><subject>Physiological aspects</subject><subject>Pneumology</subject><subject>Polysomnography - methods</subject><subject>Public Health</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>risk assessment</subject><subject>Risk factors</subject><subject>Sleep apnea</subject><subject>Sleep apnea syndromes</subject><subject>Sleep Apnea, Obstructive - epidemiology</subject><subject>Sleep Apnea, Obstructive - genetics</subject><subject>Treatment Outcome</subject><subject>Waist-Hip Ratio</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFks1v1DAQxSMEokvhyg2IQPS2W38kdnxBqiooSJU4lJ6tiT3Z9SprL3ZSqf89Xm2026Ii5ENkz2_eTJ5eUbylZEEJb87TeuHWYUGafCH8WTGjlRTzulLyeTEjnMg5qUV9UrxKaU0IqWvCXhYntGFESV7PiqubFUS05RI9Ds6ULSSXyi7EMrRpiKMZ3B2WqUfclrD1CCV4W4J125DccF9uENIYMb0uXnTQJ3wzfU-L229ff11-n1__vPpxeXE9N5KJYW6EkSgENmAaK5S0okVLJbaGVZ2lraCm5bTtBG0qyoET6KyxgjUCLANb89Piy153O7YbtAb9EKHX2-g2EO91AKcfV7xb6WW400xIxgjJAmeTQAy_R0yD3rhksO_BYxiTFopl27j6L0hVXWWUZfDjX-A6jNFnFzSjikouyG7vT3toCT1q57uQtzM7RX1BpWJV_sXdcosnqHwsbpwJHjuX3x81nD1oWCH0wyqFfhxc8OlJZRNDShG7g2WU6F2SdFrrnCQ9JSk3vH9o9BGfopOBzxMAyUDfRfDGpQOXraG1Uk3mzvdcyiW_xHi055-j3-07PAw5WwfJY_3Dvt5B0LCMeertDSOUE9IoKfPkP6hH87E</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Patel, S.R</creator><creator>Larkin, E.K</creator><creator>Redline, S</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7U1</scope><scope>7U2</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080501</creationdate><title>Shared genetic basis for obstructive sleep apnea and adiposity measures</title><author>Patel, S.R ; Larkin, E.K ; Redline, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c726t-c6c7e66e8ac8d697d6bed17ebc24fd1b61cb31bf618413a30afdcd6286ad2ad53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>abdominal fat</topic><topic>adipokines</topic><topic>Adipose tissues</topic><topic>Adiposity - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, S.R</au><au>Larkin, E.K</au><au>Redline, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shared genetic basis for obstructive sleep apnea and adiposity measures</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>32</volume><issue>5</issue><spage>795</spage><epage>800</epage><pages>795-800</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>Introduction: Obesity and obstructive sleep apnea each have a substantial genetic basis and commonly coexist in individuals. The degree to which the genetic underpinnings for these disorders overlap has not been previously quantified. Methods: A total of 1802 individuals from 310 families in the Cleveland Family Study underwent home sleep studies as well as standardized assessment of body mass index (BMI) and circumferences at the waist, hip and neck. In 713 participants with laboratory sleep studies, fasting blood samples were assayed for leptin, adiponectin and resistin. Variance component models were used to estimate heritability and genetic correlations. Results: The heritability of the apnea hypopnea index (AHI) was 0.370.04 and 0.330.07 for home and laboratory sleep studies, respectively. The genetic correlations between AHI and anthropomorphic adiposity measures ranged from 0.57 to 0.61, suggesting that obesity can explain nearly 40% of the genetic variance in sleep apnea. The magnitude of the genetic correlations between apnea severity and adipokine levels was substantially less than those with anthropomorphic measures, ranging from 0.11 to 0.46. After adjusting for BMI, no significant genetic correlation with apnea severity was observed for any of the other adiposity measures. Conclusions: Substantial but not complete overlap in genetic bases exists between sleep apnea and anthropomorphic indices of adiposity, and this overlap accounts for more than one-third of the genetic variance in apnea severity. These findings suggest that genetic polymorphisms exist that importantly influence sleep apnea susceptibility through both obesity-dependent and -independent pathways.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18209735</pmid><doi>10.1038/sj.ijo.0803803</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | abdominal fat adipokines Adipose tissues Adiposity - genetics Adult Anthropomorphism Biological and medical sciences Blood body composition Body Mass Index Care and treatment complications Critical care Diagnosis disease severity Epidemiologic Methods epidemiological studies Epidemiology Family studies Female Genetic aspects genetic correlation genetic polymorphism Genetic Predisposition to Disease - epidemiology Genetic variance genetic variation Genetics Genotype Health Promotion and Disease Prevention heritability hormone secretion Humans inheritance (genetics) Internal Medicine Laboratories Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Obesity Obesity - complications Obesity - epidemiology Obesity - genetics obesity-related diseases original-article Phenotype Physiological aspects Pneumology Polysomnography - methods Public Health Respiratory system : syndromes and miscellaneous diseases risk assessment Risk factors Sleep apnea Sleep apnea syndromes Sleep Apnea, Obstructive - epidemiology Sleep Apnea, Obstructive - genetics Treatment Outcome Waist-Hip Ratio |
| title | Shared genetic basis for obstructive sleep apnea and adiposity measures |
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