Reduced Behavioral Response to Gonadal Hormones in Mice Shipped during the Peripubertal/Adolescent Period
Animals shipped from commercial suppliers to laboratories are exposed to a wide variety of stressors. Female C57Bl6/J mice shipped during the peripubertal/adolescent period (6 wk old) display lower levels of female sexual behavior in response to estradiol and progesterone injections after ovariectom...
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| Veröffentlicht in: | Endocrinology (Philadelphia) 2009-05, Vol.150 (5), p.2351-2358 |
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| creator | Laroche, Julie Gasbarro, Lauren Herman, James P Blaustein, Jeffrey D |
| description | Animals shipped from commercial suppliers to laboratories are exposed to a wide variety of stressors. Female C57Bl6/J mice shipped during the peripubertal/adolescent period (6 wk old) display lower levels of female sexual behavior in response to estradiol and progesterone injections after ovariectomy when tested in adulthood than female mice shipped in adulthood (12 wk old). These shipping-induced reductions in female sexual behavior appear to be limited to a vulnerable period around the time of puberty. Likewise, male mice shipped at 6 wk of age express lower levels of masculine sexual behavior in response to testosterone treatment as adults than do mice shipped when 12 wk old. RIA of corticosterone levels in response to behavior testing revealed that, upon first exposure to testing, mice shipped at 6 wk of age have reduced corticosterone levels. These results suggest that during the peripubertal/adolescent period, mice of both sexes are susceptible to the effects of stressors associated with shipping. Furthermore, they suggest that stress during this period has enduring, negative influences on behavioral responses to estradiol and progesterone in females and to testosterone in males, and it induces changes in response of the hypothalamic-pituitary-adrenal axis. These results suggest that age at shipping is a critical variable that may influence many endocrinological studies, and they suggest that the peripubertal/adolescent period is a period of vulnerability to some stressors.
Mice shipped during the peripubertal/adolescent period are less responsive to the behavioral effects of gonadal hormones when tested in adulthood. |
| doi_str_mv | 10.1210/en.2008-1595 |
| format | Article |
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Mice shipped during the peripubertal/adolescent period are less responsive to the behavioral effects of gonadal hormones when tested in adulthood.</description><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/en.2008-1595</identifier><identifier>PMID: 19131570</identifier><identifier>CODEN: ENDOAO</identifier><language>eng</language><publisher>Chevy Chase, MD: Endocrine Society</publisher><subject>17β-Estradiol ; Adolescents ; Age ; Age Factors ; Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Corticosterone ; Corticosterone - blood ; Down-Regulation - drug effects ; Female ; Females ; Fundamental and applied biological sciences. Psychology ; Gonadal Hormones - pharmacology ; Handling (Psychology) ; Hormones ; Hypothalamic-pituitary-adrenal axis ; Hypothalamus ; Male ; Mice ; Mice, Inbred C57BL ; Ovariectomy ; Pituitary ; Progesterone ; Puberty ; Sex hormones ; Sexual behavior ; Sexual Behavior, Animal - drug effects ; Sexual Behavior, Animal - physiology ; Sexual Maturation - physiology ; Shipping ; Stress, Psychological - blood ; Stress, Psychological - etiology ; Stress, Psychological - physiopathology ; Testosterone ; Transportation ; Vertebrates: endocrinology</subject><ispartof>Endocrinology (Philadelphia), 2009-05, Vol.150 (5), p.2351-2358</ispartof><rights>Copyright © 2009 by The Endocrine Society 2009</rights><rights>2009 INIST-CNRS</rights><rights>Copyright © 2009 by The Endocrine Society</rights><rights>Copyright © 2009 by The Endocrine Society 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-c4c858a45da89197d812da304b58f0f432f678ba16aeedfd811531b960fabc8c3</citedby><cites>FETCH-LOGICAL-c516t-c4c858a45da89197d812da304b58f0f432f678ba16aeedfd811531b960fabc8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21453258$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19131570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laroche, Julie</creatorcontrib><creatorcontrib>Gasbarro, Lauren</creatorcontrib><creatorcontrib>Herman, James P</creatorcontrib><creatorcontrib>Blaustein, Jeffrey D</creatorcontrib><title>Reduced Behavioral Response to Gonadal Hormones in Mice Shipped during the Peripubertal/Adolescent Period</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>Animals shipped from commercial suppliers to laboratories are exposed to a wide variety of stressors. Female C57Bl6/J mice shipped during the peripubertal/adolescent period (6 wk old) display lower levels of female sexual behavior in response to estradiol and progesterone injections after ovariectomy when tested in adulthood than female mice shipped in adulthood (12 wk old). These shipping-induced reductions in female sexual behavior appear to be limited to a vulnerable period around the time of puberty. Likewise, male mice shipped at 6 wk of age express lower levels of masculine sexual behavior in response to testosterone treatment as adults than do mice shipped when 12 wk old. RIA of corticosterone levels in response to behavior testing revealed that, upon first exposure to testing, mice shipped at 6 wk of age have reduced corticosterone levels. These results suggest that during the peripubertal/adolescent period, mice of both sexes are susceptible to the effects of stressors associated with shipping. Furthermore, they suggest that stress during this period has enduring, negative influences on behavioral responses to estradiol and progesterone in females and to testosterone in males, and it induces changes in response of the hypothalamic-pituitary-adrenal axis. These results suggest that age at shipping is a critical variable that may influence many endocrinological studies, and they suggest that the peripubertal/adolescent period is a period of vulnerability to some stressors.
Mice shipped during the peripubertal/adolescent period are less responsive to the behavioral effects of gonadal hormones when tested in adulthood.</description><subject>17β-Estradiol</subject><subject>Adolescents</subject><subject>Age</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Corticosterone</subject><subject>Corticosterone - blood</subject><subject>Down-Regulation - drug effects</subject><subject>Female</subject><subject>Females</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gonadal Hormones - pharmacology</subject><subject>Handling (Psychology)</subject><subject>Hormones</subject><subject>Hypothalamic-pituitary-adrenal axis</subject><subject>Hypothalamus</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Ovariectomy</subject><subject>Pituitary</subject><subject>Progesterone</subject><subject>Puberty</subject><subject>Sex hormones</subject><subject>Sexual behavior</subject><subject>Sexual Behavior, Animal - drug effects</subject><subject>Sexual Behavior, Animal - physiology</subject><subject>Sexual Maturation - physiology</subject><subject>Shipping</subject><subject>Stress, Psychological - blood</subject><subject>Stress, Psychological - etiology</subject><subject>Stress, Psychological - physiopathology</subject><subject>Testosterone</subject><subject>Transportation</subject><subject>Vertebrates: endocrinology</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFrFTEQxoMo9rV68ywLUrx028wm2exehLbYVqgoVc8hm8z2pexL1mS34H_fPN_SKugpzMwv833DR8gboMdQAT1Bf1xR2pQgWvGMrKDlopQg6XOyohRYKatK7pH9lO5yyTlnL8ketMBASLoi7gbtbNAWZ7jW9y5EPRQ3mMbgExZTKC6D1zb3rkLcBI-pcL747AwW39ZuHPM_O0fnb4tpjcVXjG6cO4yTHk5ObRgwGfTT736wr8iLXg8JXy_vAflx8fH7-VV5_eXy0_npdWkE1FNpuGlEo7mwummhlbaBympGeSeanvacVX0tm05DrRFtn8cgGHRtTXvdmcawA_Jhtzdb2aDdOshHqTG6jY6_VNBO_T3xbq1uw72qagktbfOCd8uCGH7OmCZ1F-bos2fFgFHRSsZlpo52lIkhpYj9owJQtQ1GoVfbYNQ2mIy__dPVE7wkkYHDBdDJ6KGP2huXHrkKuGCVaDL3fseFefyfZLlIsh2J3gaTU8IxYkpP1_zT6AMJ1bS2</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Laroche, Julie</creator><creator>Gasbarro, Lauren</creator><creator>Herman, James P</creator><creator>Blaustein, Jeffrey D</creator><general>Endocrine Society</general><general>Oxford University Press</general><general>The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20090501</creationdate><title>Reduced Behavioral Response to Gonadal Hormones in Mice Shipped during the Peripubertal/Adolescent Period</title><author>Laroche, Julie ; Gasbarro, Lauren ; Herman, James P ; Blaustein, Jeffrey D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-c4c858a45da89197d812da304b58f0f432f678ba16aeedfd811531b960fabc8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>17β-Estradiol</topic><topic>Adolescents</topic><topic>Age</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Corticosterone</topic><topic>Corticosterone - blood</topic><topic>Down-Regulation - drug effects</topic><topic>Female</topic><topic>Females</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gonadal Hormones - pharmacology</topic><topic>Handling (Psychology)</topic><topic>Hormones</topic><topic>Hypothalamic-pituitary-adrenal axis</topic><topic>Hypothalamus</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Ovariectomy</topic><topic>Pituitary</topic><topic>Progesterone</topic><topic>Puberty</topic><topic>Sex hormones</topic><topic>Sexual behavior</topic><topic>Sexual Behavior, Animal - drug effects</topic><topic>Sexual Behavior, Animal - physiology</topic><topic>Sexual Maturation - physiology</topic><topic>Shipping</topic><topic>Stress, Psychological - blood</topic><topic>Stress, Psychological - etiology</topic><topic>Stress, Psychological - physiopathology</topic><topic>Testosterone</topic><topic>Transportation</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laroche, Julie</creatorcontrib><creatorcontrib>Gasbarro, Lauren</creatorcontrib><creatorcontrib>Herman, James P</creatorcontrib><creatorcontrib>Blaustein, Jeffrey D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Endocrinology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laroche, Julie</au><au>Gasbarro, Lauren</au><au>Herman, James P</au><au>Blaustein, Jeffrey D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced Behavioral Response to Gonadal Hormones in Mice Shipped during the Peripubertal/Adolescent Period</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>150</volume><issue>5</issue><spage>2351</spage><epage>2358</epage><pages>2351-2358</pages><issn>0013-7227</issn><eissn>1945-7170</eissn><coden>ENDOAO</coden><abstract>Animals shipped from commercial suppliers to laboratories are exposed to a wide variety of stressors. Female C57Bl6/J mice shipped during the peripubertal/adolescent period (6 wk old) display lower levels of female sexual behavior in response to estradiol and progesterone injections after ovariectomy when tested in adulthood than female mice shipped in adulthood (12 wk old). These shipping-induced reductions in female sexual behavior appear to be limited to a vulnerable period around the time of puberty. Likewise, male mice shipped at 6 wk of age express lower levels of masculine sexual behavior in response to testosterone treatment as adults than do mice shipped when 12 wk old. RIA of corticosterone levels in response to behavior testing revealed that, upon first exposure to testing, mice shipped at 6 wk of age have reduced corticosterone levels. These results suggest that during the peripubertal/adolescent period, mice of both sexes are susceptible to the effects of stressors associated with shipping. Furthermore, they suggest that stress during this period has enduring, negative influences on behavioral responses to estradiol and progesterone in females and to testosterone in males, and it induces changes in response of the hypothalamic-pituitary-adrenal axis. These results suggest that age at shipping is a critical variable that may influence many endocrinological studies, and they suggest that the peripubertal/adolescent period is a period of vulnerability to some stressors.
Mice shipped during the peripubertal/adolescent period are less responsive to the behavioral effects of gonadal hormones when tested in adulthood.</abstract><cop>Chevy Chase, MD</cop><pub>Endocrine Society</pub><pmid>19131570</pmid><doi>10.1210/en.2008-1595</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Endocrinology (Philadelphia), 2009-05, Vol.150 (5), p.2351-2358 |
| issn | 0013-7227 1945-7170 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 17β-Estradiol Adolescents Age Age Factors Animals Behavior, Animal - drug effects Biological and medical sciences Corticosterone Corticosterone - blood Down-Regulation - drug effects Female Females Fundamental and applied biological sciences. Psychology Gonadal Hormones - pharmacology Handling (Psychology) Hormones Hypothalamic-pituitary-adrenal axis Hypothalamus Male Mice Mice, Inbred C57BL Ovariectomy Pituitary Progesterone Puberty Sex hormones Sexual behavior Sexual Behavior, Animal - drug effects Sexual Behavior, Animal - physiology Sexual Maturation - physiology Shipping Stress, Psychological - blood Stress, Psychological - etiology Stress, Psychological - physiopathology Testosterone Transportation Vertebrates: endocrinology |
| title | Reduced Behavioral Response to Gonadal Hormones in Mice Shipped during the Peripubertal/Adolescent Period |
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