Identification of the Potent Phytoestrogen Glycinol in Elicited Soybean (Glycine max)

The primary induced isoflavones in soybean, the glyceollins, have been shown to be potent estrogen antagonists in vitro and in vivo. The discovery of the glyceollins’ ability to inhibit cancer cell proliferation has led to the analysis of estrogenic activities of other induced isoflavones. In this s...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-05, Vol.150 (5), p.2446-2453
Hauptverfasser:	Boué, Stephen M, Tilghman, Syreeta L, Elliott, Steven, Zimmerman, M. Carla, Williams, K. Y, Payton-Stewart, Florastina, Miraflor, Allen P, Howell, Melanie H, Shih, Betty Y, Carter-Wientjes, Carol H, Segar, Chris, Beckman, Barbara S, Wiese, Thomas E, Cleveland, Thomas E, McLachlan, John A, Burow, Matthew E
Format:	Artikel
Sprache:	eng
Schlagworte:	binding capacity Binding, Competitive Bioassays Biological and medical sciences Cell Proliferation Cell Proliferation - drug effects Cells, Cultured chemistry drug effects Drug Evaluation, Preclinical Estrogen receptors Estrogenic activity estrogenic properties Estrogens Estrogens - isolation & purification Estrogens - metabolism Estrogens - pharmacology Fermentation Fermentation - physiology Flavonols Flavonols - chemistry Flavonols - isolation & purification Flavonols - metabolism Flavonols - pharmacology Fundamental and applied biological sciences. Psychology gene expression regulation Gene Expression Regulation - drug effects Glycine max Glycine max - chemistry Glycine max - metabolism glycinol hormone receptors Humans In vivo methods and tests Isoflavones isolation & purification metabolism Models, Biological Models, Molecular pharmacology physiology Phytoestrogens Phytoestrogens - chemistry Phytoestrogens - isolation & purification Phytoestrogens - metabolism Phytoestrogens - pharmacology Progesterone Pterocarpans Pterocarpans - chemistry Receptors Receptors, Estrogen Receptors, Estrogen - metabolism Receptors, Estrogen - physiology Soybeans Transcription, Genetic Transcription, Genetic - drug effects Vertebrates: endocrinology Xenoestrogens
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