Antagonism of Oxytocin Prevents Suckling- and Estradiol-Induced, But Not Progesterone-Induced, Secretion of Prolactin

In female rats, estradiol (E2) and suckling induce prolactin (PRL) secretion. This involves inhibition of hypothalamic dopaminergic tone and stimulation by a PRL-releasing hormone, possibly oxytocin (OT). Infusing an OT antagonist (OTA) iv, we evaluated the role of OT on suckling- and E2-induced PRL...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-05, Vol.150 (5), p.2292-2299
Hauptverfasser:	Kennett, Jessica E, Poletini, Maristela O, Fitch, Cheryl A, Freeman, Marc E
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Animals, Newborn Animals, Suckling Biological and medical sciences Blood Breastfeeding & lactation Dopamine receptors Estradiol - pharmacology Female Fundamental and applied biological sciences. Psychology Hormones Hypothalamus Infusion Pumps Juveniles Lactation Lactation - drug effects Ornipressin - administration & dosage Ornipressin - analogs & derivatives Ornipressin - pharmacology Ovariectomy Ovariectomy - veterinary Oxytocin Oxytocin - antagonists & inhibitors Oxytocin - physiology Parturition Pituitary (anterior) Progesterone Progesterone - pharmacology Prolactin Prolactin - secretion Rats Rats, Sprague-Dawley Secretion Sex hormones Sucking Behavior - drug effects Suckling behavior Vertebrates: endocrinology
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