Essential Role for Macrophage Migration Inhibitory Factor in Gastritis Induced by Helicobacter pylori

Macrophage migration inhibitory factor (MIF) is an upstream regulator of immune and inflammatory responses; however, its role in Helicobacter pylori (HP)-associated gastritis remains unknown. We infected MIF knockout (KO) and wild-type mice with SS1 HP and found that 2 weeks after infection, MIF and...

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Veröffentlicht in:	The American journal of pathology 2009-04, Vol.174 (4), p.1319-1328
Hauptverfasser:	Wong, Benny L.W, Zhu, Sen-Lin, Huang, Xiao R, Ma, Juan, Xia, Harry H.X, Bucala, Richard, Wong, Benjamin C.Y, Lan, Hui Yao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial Antigens, Differentiation, B-Lymphocyte - immunology Antigens, Differentiation, B-Lymphocyte - metabolism Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Cell Differentiation - immunology Flow Cytometry Gastritis - immunology Gastritis - microbiology Helicobacter Infections - immunology Helicobacter pylori Helicobacter pylori - immunology Histocompatibility Antigens Class II - immunology Histocompatibility Antigens Class II - metabolism Human bacterial diseases Hypersensitivity, Delayed Immunohistochemistry Infectious diseases Intercellular Adhesion Molecule-1 - immunology Intercellular Adhesion Molecule-1 - metabolism Intramolecular Oxidoreductases - immunology Intramolecular Oxidoreductases - metabolism Investigative techniques, diagnostic techniques (general aspects) Macrophage Migration-Inhibitory Factors - immunology Macrophage Migration-Inhibitory Factors - metabolism Medical sciences Mice Mice, Knockout Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Regular Reverse Transcriptase Polymerase Chain Reaction Th1 Cells - cytology Th1 Cells - immunology Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism
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