Characterization of a Hapten-Induced, Murine Model with Multiple Features of Atopic Dermatitis: Structural, Immunologic, and Biochemical Changes following Single Versus Multiple Oxazolone Challenges

Atopic dermatitis (AD) is a chronic dermatosis bearing clinical, histological, and immunologic similarities to chronic allergic contact dermatitis (ACD). AD shows a Th2 cell-dominant inflammatory infiltrate, elevated serum IgE levels, a permeability barrier abnormality, and Staphylococcus aureas col...

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Veröffentlicht in:	Journal of investigative dermatology 2008-01, Vol.128 (1), p.79-86
Hauptverfasser:	Man, Mao-Qiang, Hatano, Yutaka, Lee, Seung H., Man, Mona, Chang, Sandra, Feingold, Kenneth R., Leung, Donald Y.M., Holleran, Walter, Uchida, Yoshikazu, Elias, Peter M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic diseases Animal models Animals Antimicrobial Cationic Peptides - analysis Antimicrobial peptides Atopic dermatitis Biological and medical sciences Cathelicidins Ceramide Ceramides - analysis Colonization Contact dermatitis Dermatitis, Atopic - immunology Dermatitis, Atopic - metabolism Dermatology Differentiation Disease Models, Animal DNA-Binding Proteins - analysis Female Filaggrin Hairless Haptens Haptens - administration & dosage Haptens - immunology Helper cells Hypersensitivity Immunity, Innate - drug effects Immunoglobulin E Immunoglobulin E - blood Immunopathology Inflammation Interleukin 4 Internet Lipids - analysis Lymphocytes T MBD3 protein Medical sciences Mice Mice, Hairless oxazolone Oxazolone - administration & dosage Oxazolone - immunology Permeability Serine Endopeptidases - metabolism Serine proteinase Skin Skin allergic diseases. Stinging insect allergies Staphylococcus Stratum corneum Th2 Cells - immunology Transcription Factors - analysis
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