Polypurine Hairpins Directed against the Template Strand of DNA Knock Down the Expression of Mammalian Genes

We analyzed whether polypurine hairpins (PPRHs) had the ability to knock down gene expression. These hairpins are formed by two antiparallel purine domains linked by a loop that allows the formation of Hoogsteen bonds between both domains and Watson-Crick bonds with the target polypyrimidine sequenc...

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