Transforming Growth Factor β1-mediated Activation of the Smooth Muscle α-Actin Gene in Human Pulmonary Myofibroblasts Is Inhibited by Tumor Necrosis Factor-α via Mitogen-activated Protein Kinase Kinase 1-dependent Induction of the Egr-1 Transcriptional Repressor

Transforming growth factor (TGF) β1 is a mediator of myofibroblast differentiation in healing wounds in which it activates transcription of the smooth muscle α-actin (SMαA) gene via dynamic interplay of nuclear activators and repressors. Targeting components of TGFβ1 signaling may be an effective st...

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Veröffentlicht in:	Molecular biology of the cell 2009-04, Vol.20 (8), p.2174-2185
Hauptverfasser:	Liu, Xiaoying, Kelm, Robert J., Strauch, Arthur R.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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