Role of Goiter and of Menstrual and Reproductive Factors in Thyroid Cancer: A Population-based Case-Control Study in New Caledonia (South Pacific), a Very High Incidence Area
Exceptionally high incidence rates of thyroid cancer have been reported for Melanesian women in New Caledonia (South Pacific). To investigate the occurrence of thyroid cancer in that country and to clarify the role of goiter and hormonal factors in that disease in women, a countrywide population-bas...
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| Veröffentlicht in: | American journal of epidemiology 2005-06, Vol.161 (11), p.1056-1065 |
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| creator | Truong, Thérèse Orsi, Laurent Dubourdieu, Dominique Rougier, Yannick Hémon, Denis Guénel, Pascal |
| description | Exceptionally high incidence rates of thyroid cancer have been reported for Melanesian women in New Caledonia (South Pacific). To investigate the occurrence of thyroid cancer in that country and to clarify the role of goiter and hormonal factors in that disease in women, a countrywide population-based case-control study was conducted in 1993–1999. The study included 293 cases, identified through pathology registers and whose thyroid cancer was verified histologically, and 354 population controls. Thyroid cancer was associated with goiter, age at menarche, irregular menstruation, and hysterectomy. There was a dose-response trend with number of full-term pregnancies (p = 0.01), with an odds ratio of 2.2 (95% confidence interval: 1.1, 4.3) for women with eight or more pregnancies. Miscarriage, particularly as an outcome of the first pregnancy, was also indicated as a risk factor. The association between voluntary abortion and thyroid microcarcinoma could be explained by enhanced medical surveillance and improved cancer detection in women undergoing abortion. Oral contraceptives and hormone replacement therapy were unrelated to thyroid cancer. The very high birth rate among Melanesian women in New Caledonia, as well as late age at menarche, may explain, in part, their elevated incidence of thyroid cancer. |
| doi_str_mv | 10.1093/aje/kwi136 |
| format | Article |
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To investigate the occurrence of thyroid cancer in that country and to clarify the role of goiter and hormonal factors in that disease in women, a countrywide population-based case-control study was conducted in 1993–1999. The study included 293 cases, identified through pathology registers and whose thyroid cancer was verified histologically, and 354 population controls. Thyroid cancer was associated with goiter, age at menarche, irregular menstruation, and hysterectomy. There was a dose-response trend with number of full-term pregnancies (p = 0.01), with an odds ratio of 2.2 (95% confidence interval: 1.1, 4.3) for women with eight or more pregnancies. Miscarriage, particularly as an outcome of the first pregnancy, was also indicated as a risk factor. The association between voluntary abortion and thyroid microcarcinoma could be explained by enhanced medical surveillance and improved cancer detection in women undergoing abortion. Oral contraceptives and hormone replacement therapy were unrelated to thyroid cancer. The very high birth rate among Melanesian women in New Caledonia, as well as late age at menarche, may explain, in part, their elevated incidence of thyroid cancer.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwi136</identifier><identifier>PMID: 15901626</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Abortion, Spontaneous ; Adult ; Age of Onset ; Aged ; Analysis. Health state ; Biological and medical sciences ; Case-Control Studies ; Endocrinopathies ; Epidemiology ; Female ; General aspects ; goiter ; Goiter - complications ; Humans ; Incidence ; Malignant tumors ; Medical sciences ; Menarche ; menopause ; Menstruation ; Menstruation Disturbances ; Middle Aged ; New Caledonia ; New Caledonia - epidemiology ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; odds ratio ; Parity ; Pregnancy ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Thyroid cancer ; Thyroid gland ; thyroid neoplasms ; Thyroid Neoplasms - epidemiology ; Thyroid Neoplasms - etiology ; Thyroid. Thyroid axis (diseases) ; Women</subject><ispartof>American journal of epidemiology, 2005-06, Vol.161 (11), p.1056-1065</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jun 1, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-640b2869fe07b25d4e15569d43dfa28e51c1b443d9f2aee4c678e343e0d637093</citedby><cites>FETCH-LOGICAL-c471t-640b2869fe07b25d4e15569d43dfa28e51c1b443d9f2aee4c678e343e0d637093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16888194$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15901626$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Truong, Thérèse</creatorcontrib><creatorcontrib>Orsi, Laurent</creatorcontrib><creatorcontrib>Dubourdieu, Dominique</creatorcontrib><creatorcontrib>Rougier, Yannick</creatorcontrib><creatorcontrib>Hémon, Denis</creatorcontrib><creatorcontrib>Guénel, Pascal</creatorcontrib><title>Role of Goiter and of Menstrual and Reproductive Factors in Thyroid Cancer: A Population-based Case-Control Study in New Caledonia (South Pacific), a Very High Incidence Area</title><title>American journal of epidemiology</title><addtitle>Am. J. Epidemiol</addtitle><description>Exceptionally high incidence rates of thyroid cancer have been reported for Melanesian women in New Caledonia (South Pacific). To investigate the occurrence of thyroid cancer in that country and to clarify the role of goiter and hormonal factors in that disease in women, a countrywide population-based case-control study was conducted in 1993–1999. The study included 293 cases, identified through pathology registers and whose thyroid cancer was verified histologically, and 354 population controls. Thyroid cancer was associated with goiter, age at menarche, irregular menstruation, and hysterectomy. There was a dose-response trend with number of full-term pregnancies (p = 0.01), with an odds ratio of 2.2 (95% confidence interval: 1.1, 4.3) for women with eight or more pregnancies. Miscarriage, particularly as an outcome of the first pregnancy, was also indicated as a risk factor. The association between voluntary abortion and thyroid microcarcinoma could be explained by enhanced medical surveillance and improved cancer detection in women undergoing abortion. Oral contraceptives and hormone replacement therapy were unrelated to thyroid cancer. The very high birth rate among Melanesian women in New Caledonia, as well as late age at menarche, may explain, in part, their elevated incidence of thyroid cancer.</description><subject>Abortion, Spontaneous</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Analysis. Health state</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Endocrinopathies</subject><subject>Epidemiology</subject><subject>Female</subject><subject>General aspects</subject><subject>goiter</subject><subject>Goiter - complications</subject><subject>Humans</subject><subject>Incidence</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Menarche</subject><subject>menopause</subject><subject>Menstruation</subject><subject>Menstruation Disturbances</subject><subject>Middle Aged</subject><subject>New Caledonia</subject><subject>New Caledonia - epidemiology</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>odds ratio</subject><subject>Parity</subject><subject>Pregnancy</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Thyroid cancer</subject><subject>Thyroid gland</subject><subject>thyroid neoplasms</subject><subject>Thyroid Neoplasms - epidemiology</subject><subject>Thyroid Neoplasms - etiology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Women</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkt1uEzEQhVcIREPhhgdAFlIRIJb6Z-31coEUItqUFqiaghA3luOdbZxu7GDvtuSleEYcErXAlTU-n8_MeCbLHhP8muCK7es57F9eW8LEnWxAilLkgnJxNxtgjGleUUF3sgcxzjEmpOL4frZDeIWJoGKQ_TrzLSDfoENvOwhIu3odfQQXu9Dr9s_FGSyDr3vT2StAB9p0PkRkHTqfrYK3NRppZyC8QUN06pd9qzvrXT7VEdZShHzkXRd8iyZdX6_WDz_BdVJaqL2zGj2f-L6boVNtbGPNi1dIo68QVmhsL2boyBlbQ_JHwwD6YXav0W2ER9tzN_ty8P58NM5PPh8ejYYnuSlK0uWiwFMqRdUALqeU1wUQzkVVF6xuNJXAiSHTIkVVQzVAYUQpgRUMcC1Ymf50N3u78V320wXUBlIDulXLYBc6rJTXVv2rODtTF_5KUSFkxUQyeLY1CP5HD7FTCxsNtK124PuoUkImMVtnevofOPd9cKk5RRmXBS4kS9DLDWSCjzFAc1MJwWq9AyrtgNrsQIKf_F37LbodegL2toCORrdNSOOz8ZYTUkpSFYnLN5yNHfy80XW4TOWzkqvxt--KH0t8zCcf1Dv2G5pyysQ</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Truong, Thérèse</creator><creator>Orsi, Laurent</creator><creator>Dubourdieu, Dominique</creator><creator>Rougier, Yannick</creator><creator>Hémon, Denis</creator><creator>Guénel, Pascal</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20050601</creationdate><title>Role of Goiter and of Menstrual and Reproductive Factors in Thyroid Cancer: A Population-based Case-Control Study in New Caledonia (South Pacific), a Very High Incidence Area</title><author>Truong, Thérèse ; Orsi, Laurent ; Dubourdieu, Dominique ; Rougier, Yannick ; Hémon, Denis ; Guénel, Pascal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-640b2869fe07b25d4e15569d43dfa28e51c1b443d9f2aee4c678e343e0d637093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Abortion, Spontaneous</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Analysis. Health state</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Endocrinopathies</topic><topic>Epidemiology</topic><topic>Female</topic><topic>General aspects</topic><topic>goiter</topic><topic>Goiter - complications</topic><topic>Humans</topic><topic>Incidence</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Menarche</topic><topic>menopause</topic><topic>Menstruation</topic><topic>Menstruation Disturbances</topic><topic>Middle Aged</topic><topic>New Caledonia</topic><topic>New Caledonia - epidemiology</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>odds ratio</topic><topic>Parity</topic><topic>Pregnancy</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Thyroid cancer</topic><topic>Thyroid gland</topic><topic>thyroid neoplasms</topic><topic>Thyroid Neoplasms - epidemiology</topic><topic>Thyroid Neoplasms - etiology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Truong, Thérèse</creatorcontrib><creatorcontrib>Orsi, Laurent</creatorcontrib><creatorcontrib>Dubourdieu, Dominique</creatorcontrib><creatorcontrib>Rougier, Yannick</creatorcontrib><creatorcontrib>Hémon, Denis</creatorcontrib><creatorcontrib>Guénel, Pascal</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Truong, Thérèse</au><au>Orsi, Laurent</au><au>Dubourdieu, Dominique</au><au>Rougier, Yannick</au><au>Hémon, Denis</au><au>Guénel, Pascal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Goiter and of Menstrual and Reproductive Factors in Thyroid Cancer: A Population-based Case-Control Study in New Caledonia (South Pacific), a Very High Incidence Area</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am. J. Epidemiol</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>161</volume><issue>11</issue><spage>1056</spage><epage>1065</epage><pages>1056-1065</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>Exceptionally high incidence rates of thyroid cancer have been reported for Melanesian women in New Caledonia (South Pacific). To investigate the occurrence of thyroid cancer in that country and to clarify the role of goiter and hormonal factors in that disease in women, a countrywide population-based case-control study was conducted in 1993–1999. The study included 293 cases, identified through pathology registers and whose thyroid cancer was verified histologically, and 354 population controls. Thyroid cancer was associated with goiter, age at menarche, irregular menstruation, and hysterectomy. There was a dose-response trend with number of full-term pregnancies (p = 0.01), with an odds ratio of 2.2 (95% confidence interval: 1.1, 4.3) for women with eight or more pregnancies. Miscarriage, particularly as an outcome of the first pregnancy, was also indicated as a risk factor. The association between voluntary abortion and thyroid microcarcinoma could be explained by enhanced medical surveillance and improved cancer detection in women undergoing abortion. Oral contraceptives and hormone replacement therapy were unrelated to thyroid cancer. The very high birth rate among Melanesian women in New Caledonia, as well as late age at menarche, may explain, in part, their elevated incidence of thyroid cancer.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>15901626</pmid><doi>10.1093/aje/kwi136</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Abortion, Spontaneous Adult Age of Onset Aged Analysis. Health state Biological and medical sciences Case-Control Studies Endocrinopathies Epidemiology Female General aspects goiter Goiter - complications Humans Incidence Malignant tumors Medical sciences Menarche menopause Menstruation Menstruation Disturbances Middle Aged New Caledonia New Caledonia - epidemiology Non tumoral diseases. Target tissue resistance. Benign neoplasms odds ratio Parity Pregnancy Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Thyroid cancer Thyroid gland thyroid neoplasms Thyroid Neoplasms - epidemiology Thyroid Neoplasms - etiology Thyroid. Thyroid axis (diseases) Women |
| title | Role of Goiter and of Menstrual and Reproductive Factors in Thyroid Cancer: A Population-based Case-Control Study in New Caledonia (South Pacific), a Very High Incidence Area |
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