Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity

Individual differences in traits such as impulsivity involve high reward sensitivity and are associated with risk for substance use disorders. The ventral striatum (VS) has been widely implicated in reward processing, and individual differences in its function are linked to these disorders. Dopamine...

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Veröffentlicht in:	Molecular psychiatry 2009-01, Vol.14 (1), p.60-70
Hauptverfasser:	Forbes, E E, Brown, S M, Kimak, M, Ferrell, R E, Manuck, S B, Hariri, A R
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Addictive behaviors Adult Analysis Analysis of Variance Basal Ganglia - blood supply Basal Ganglia - physiopathology Behavior Behavioral Sciences Biological and medical sciences Biological Psychology Case-Control Studies Catechol O-Methyltransferase - genetics Decision making Dopamine Dopamine - genetics Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins - genetics Dopamine receptors Drug use Female Gene Frequency Genetic aspects Genetic polymorphisms Genetic Variation - genetics Genotype Health aspects Humans Image Processing, Computer-Assisted - methods Impulsive Behavior - genetics Impulsive Behavior - pathology Impulsivity Magnetic Resonance Imaging - methods Male Medical sciences Medicine Medicine & Public Health Middle Aged Neural transmission Neurobiology Neurosciences original-article Oxygen - blood Pharmacotherapy Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Dopamine D3 - genetics Receptors, Dopamine D4 - genetics Regulation Reward Substance use disorder Synaptic Transmission - genetics Young Adult
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