Neuraminidase Stalk Length and Additional Glycosylation of the Hemagglutinin Influence the Virulence of Influenza H5N1 Viruses for Mice

Following circulation of avian influenza H5 and H7 viruses in poultry, the hemagglutinin (HA) can acquire additional glycosylation sites, and the neuraminidase (NA) stalk becomes shorter. We investigated whether these features play a role in the pathogenesis of infection in mammalian hosts. From 199...

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Veröffentlicht in:	Journal of Virology 2009-05, Vol.83 (9), p.4704-4708
Hauptverfasser:	Matsuoka, Yumiko, Swayne, David E, Thomas, Colleen, Rameix-Welti, Marie-Anne, Naffakh, Nadia, Warnes, Christine, Altholtz, Melanie, Donis, Ruben, Subbarao, Kanta
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals avian influenza Biological and medical sciences Chickens enzyme activity Erythrocytes - metabolism Fundamental and applied biological sciences. Psychology Glycosylation Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - metabolism hemagglutinins Influenza A virus Influenza A Virus, H5N1 Subtype - classification Influenza A Virus, H5N1 Subtype - enzymology Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - pathogenicity mice Mice - virology Microbiology Miscellaneous Mutation - genetics Neuraminidase - chemistry Neuraminidase - genetics Neuraminidase - metabolism Orthomyxoviridae Infections Pathogenesis and Immunity poultry poultry diseases protein structure sialidase strains Time Factors viral diseases of animals and humans Virology Virulence waterfowl wild birds
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