A Short Nur77-Derived Peptide Converts Bcl-2 from a Protector to a Killer

Bcl-2 can be converted into a proapoptotic molecule by nuclear receptor Nur77. However, the development of Bcl-2 converters as anticancer therapeutics has not been explored. Here we report the identification of a Nur77-derived Bcl-2-converting peptide with 9 amino acids (NuBCP-9) and its enantiomer,...

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Veröffentlicht in:	Cancer cell 2008-10, Vol.14 (4), p.285-298
Hauptverfasser:	Kolluri, Siva Kumar, Zhu, Xiuwen, Zhou, Xin, Lin, Bingzhen, Chen, Ya, Sun, Kai, Tian, Xuefei, Town, James, Cao, Xihua, Lin, Feng, Zhai, Dayong, Kitada, Shinichi, Luciano, Frederick, O'Donnell, Edmond, Cao, Yu, He, Feng, Lin, Jialing, Reed, John C., Satterthwait, Arnold C., Zhang, Xiao-kun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism bcl-X Protein - metabolism BH3 Interacting Domain Death Agonist Protein - metabolism Binding Sites Cell Proliferation - drug effects Cell Survival - drug effects CELLBIO DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Female HeLa Cells Humans HUMDISEASE Jurkat Cells Mice Mice, Knockout Mice, SCID Neoplasms, Experimental - drug therapy Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Nuclear Receptor Subfamily 4, Group A, Member 1 Oligopeptides - chemistry Oligopeptides - pharmacology Peptide Fragments - pharmacology Protein Binding Protein Conformation Protein Structure, Tertiary PROTEINS Proto-Oncogene Proteins - pharmacology Proto-Oncogene Proteins c-bcl-2 - chemistry Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Receptors, Steroid - genetics Receptors, Steroid - metabolism Stereoisomerism Time Factors Transfection Xenograft Model Antitumor Assays
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