JDP2 (Jun Dimerization Protein 2)-deficient Mouse Embryonic Fibroblasts Are Resistant to Replicative Senescence

JDP2 (Jun dimerization protein 2, an AP-1 transcription factor) is involved in the regulation of the differentiation and proliferation of cells. We report here that JDP2-deficient mouse embryonic fibroblasts (Jdp2-/- MEF) are resistant to replicative senescence. In the absence of JDP2, the level of...

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Veröffentlicht in:	The Journal of biological chemistry 2009-04, Vol.284 (16), p.10808-10817
Hauptverfasser:	Nakade, Koji, Pan, Jianzhi, Yamasaki, Takahito, Murata, Takehide, Wasylyk, Bohdan, Yokoyama, Kazunari K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle - physiology Cell Proliferation Cells, Cultured Cellular Senescence - physiology Chromatin - metabolism Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Epigenesis, Genetic Fibroblasts - cytology Fibroblasts - physiology Gene Expression Regulation Histones - metabolism Methylation Mice Mice, Knockout Promoter Regions, Genetic Repressor Proteins - genetics Repressor Proteins - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction - physiology Time Factors Transcription, Chromatin, and Epigenetics
Online-Zugang:	Volltext
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