Circadian Regulation of cGMP-Gated Channels of Vertebrate Cone Photoreceptors: Role of cAMP and Ras

Circadian oscillators in chicken cone photoreceptors regulate the gating properties of cGMP-gated cationic channels (CNGCs) such that they have a higher apparent affinity for cGMP during the subjective night. Here we show that cAMP, acting through protein kinase A (PKA), Ras, and Erk, is part of the...

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Veröffentlicht in:	The Journal of neuroscience 2004-02, Vol.24 (6), p.1296-1304
Hauptverfasser:	Ko, Gladys Y.-P, Ko, Michael L, Dryer, Stuart E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biolistics Cells, Cultured Cellular/Molecular Chick Embryo Circadian Rhythm - drug effects Circadian Rhythm - genetics Circadian Rhythm - physiology Cyclic AMP - antagonists & inhibitors Cyclic AMP - metabolism Cyclic AMP - pharmacology Cyclic AMP-Dependent Protein Kinases - metabolism Cyclic Nucleotide-Gated Cation Channels Darkness Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Genes, Dominant Ion Channel Gating - drug effects Ion Channel Gating - physiology Ion Channels - metabolism Light Mitogen-Activated Protein Kinases - drug effects Mitogen-Activated Protein Kinases - metabolism Patch-Clamp Techniques Polyenes - pharmacology Polyunsaturated Alkamides Proto-Oncogene Proteins c-raf - genetics Proto-Oncogene Proteins c-raf - metabolism ras Proteins - drug effects ras Proteins - genetics ras Proteins - metabolism Retinal Cone Photoreceptor Cells - cytology Retinal Cone Photoreceptor Cells - metabolism Retinal Cone Photoreceptor Cells - radiation effects Signal Transduction - drug effects Signal Transduction - physiology
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