From 3D to 2D: A Review of the Molecular Imprinting of Proteins
Molecular imprinting is a generic technology that allows for the introduction of sites of specific molecular affinity into otherwise homogeneous polymeric matrices. Commonly this technique has been shown to be effective when targeting small molecules of molecular weight
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Veröffentlicht in: | Biotechnology progress 2006-12, Vol.22 (6), p.1474-1489 |
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container_title | Biotechnology progress |
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creator | Turner, Nicholas W. Jeans, Christopher W. Brain, Keith R. Allender, Christopher J. Hlady, Vladimir Britt, David W. |
description | Molecular imprinting is a generic technology that allows for the introduction of sites of specific molecular affinity into otherwise homogeneous polymeric matrices. Commonly this technique has been shown to be effective when targeting small molecules of molecular weight |
doi_str_mv | 10.1021/bp060122g |
format | Article |
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Commonly this technique has been shown to be effective when targeting small molecules of molecular weight <1500, while extending the technique to larger molecules such as proteins has proven difficult. A number of key inherent problems in protein imprinting have been identified, including permanent entrapment, poor mass transfer, denaturation, and heterogeneity in binding pocket affinity, which have been addressed using a variety of approaches. 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source | Wiley Online Library Journals Frontfile Complete |
title | From 3D to 2D: A Review of the Molecular Imprinting of Proteins |
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