Use of Penalized Splines in Extended Cox-Type Additive Hazard Regression to Flexibly Estimate the Effect of Time-varying Serum Uric Acid on Risk of Cancer Incidence: A Prospective, Population-Based Study in 78,850 Men

Purpose We sough to investigate the effect of serum uric acid (SUA) levels on risk of cancer incidence in men and to flexibly determine the shape of this association by using a novel analytical approach. Methods A population-based cohort of 78,850 Austrian men who received 264,347 serial SUA measure...

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Veröffentlicht in:	Annals of epidemiology 2009-01, Vol.19 (1), p.15-24
Hauptverfasser:	Strasak, Alexander M., PhD, Lang, Stefan, PhD, Kneib, Thomas, PhD, Brant, Larry J., PhD, Klenk, Jochen, MSc, Hilbe, Wolfgang, MD, Oberaigner, Willi, PhD, Ruttmann, Elfriede, MD, Kaltenbach, Lalit, Concin, Hans, MD, Diem, Günter, MD, Pfeiffer, Karl P., PhD, Ulmer, Hanno, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biomarkers Cancer incidence Epidemiology Extended Cox-type additive hazard regression Humans Incidence Internal Medicine Male Men Middle Aged Neoplasms - blood Neoplasms - epidemiology Penalized splines Proportional Hazards Models Prospective Studies Risk factor Serum uric acid Time Factors Uric Acid - blood Young Adult
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