Mechanistic Insights into the Hydrolysis and Synthesis of Ceramide by Neutral Ceramidase

Ceramidase (CDase; EC 3.5.1.23) hydrolyzes ceramide to generate sphingosine and fatty acid. The enzyme plays a regulatory role in a variety of physiological events in eukaryotes and also functions as an exotoxin in particular bacteria. The crystal structures of neutral CDase from Pseudomonas aerugin...

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Veröffentlicht in:	The Journal of biological chemistry 2009-04, Vol.284 (14), p.9566-9577
Hauptverfasser:	Inoue, Tsuyoshi, Okino, Nozomu, Kakuta, Yoshimitsu, Hijikata, Atsushi, Okano, Hiroyuki, Goda, Hatsumi M., Tani, Motohiro, Sueyoshi, Noriyuki, Kambayashi, Kouji, Matsumura, Hiroyoshi, Kai, Yasushi, Ito, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Catalytic Domain Cell Line Ceramides - chemistry Ceramides - metabolism Crystallography, X-Ray Humans Hydrolysis Lipids and Lipoproteins: Metabolism, Regulation, and Signaling Metals - chemistry Metals - metabolism Models, Molecular Molecular Sequence Data Mutation - genetics Neutral Ceramidase - chemistry Neutral Ceramidase - genetics Neutral Ceramidase - metabolism Protein Structure, Tertiary Pseudomonas aeruginosa - enzymology Pseudomonas aeruginosa - genetics Rats Sequence Alignment Sequence Homology, Amino Acid Substrate Specificity
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