Brief constant light accelerates serotonergic re-entrainment to large shifts of the daily light/dark cycle
Abstract Brief (∼2 day) constant light exposure (LLb ) in hamsters dramatically enhances circadian phase-resetting induced by the 5-HT receptor agonist, (±)-2-dipropyl-amino-8-hydroxyl-1,2,3,4-tetrahydronapthalene (8-OH-DPAT) and other nonphotic stimuli. The present study was undertaken to determine...
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| description | Abstract Brief (∼2 day) constant light exposure (LLb ) in hamsters dramatically enhances circadian phase-resetting induced by the 5-HT receptor agonist, (±)-2-dipropyl-amino-8-hydroxyl-1,2,3,4-tetrahydronapthalene (8-OH-DPAT) and other nonphotic stimuli. The present study was undertaken to determine if LLb can also amplify phase-resetting responses to endogenous 5-HT and accelerate re-entrainment to large-magnitude advance and delay shifts of the light/dark (LD) cycle. First, central serotonergic activity was increased by i.p. injection of l -tryptophan±the 5-HT reuptake inhibitor fluoxetine. Hamsters under LD or exposed to LLb received vehicle or drugs during the early morning, and phase-shifts of the locomotor activity rhythm were measured after release to constant darkness. Neither drug phase-shifted animals not exposed to LLb ( P >0.5 vs. vehicle); however in animals receiving LLb, l -tryptophan with and without fluoxetine produced large phase-advance shifts (means=2.5±0.4 h and 2.6±0.2 h, respectively; both P |
| doi_str_mv | 10.1016/j.neuroscience.2009.02.016 |
| format | Article |
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The present study was undertaken to determine if LLb can also amplify phase-resetting responses to endogenous 5-HT and accelerate re-entrainment to large-magnitude advance and delay shifts of the light/dark (LD) cycle. First, central serotonergic activity was increased by i.p. injection of l -tryptophan±the 5-HT reuptake inhibitor fluoxetine. Hamsters under LD or exposed to LLb received vehicle or drugs during the early morning, and phase-shifts of the locomotor activity rhythm were measured after release to constant darkness. Neither drug phase-shifted animals not exposed to LLb ( P >0.5 vs. vehicle); however in animals receiving LLb, l -tryptophan with and without fluoxetine produced large phase-advance shifts (means=2.5±0.4 h and 2.6±0.2 h, respectively; both P <0.035 vs. vehicle). Next, the effects of LLb combined with 8-OH-DPAT or l -tryptophan+fluoxetine on serotonergic re-entrainment to 10 h phase-advance and phase-delay shifts of the LD cycle were assessed. In groups not exposed to LLb , vehicle controls re-entrained slowly to the advance and delay shifts (means=16±1 and 24±4 days, respectively), but those treated with 8-OH-DPAT re-entrained faster (means=11±2 and 9±2 days, respectively; both P <0.05 vs. vehicle). In groups exposed to LLb , vehicle controls re-entrained slowly to the advance and delay shifts (means=15±2 and 25±3 days, respectively); however those receiving 8-OH-DPAT rapidly re-entrained to the delay and advance shifts, with the majority (75%) requiring only 1–2 days (means=2±1 and 4±2 days, respectively; both P <0.05 vs. vehicle). Animals exposed to LLb and treated with l -tryptophan+fluoxetine also exhibited accelerated re-entrainment to a 10 h advance shift (mean=5±2 days; P <0.05 vs. vehicle). Thus through enhancing serotonergic phase-resetting, LLb facilitates rapid re-entrainment to large shifts of the LD cycle which offers a potential approach for treating circadian-related desynchronies.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2009.02.016</identifier><identifier>PMID: 19217929</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject><![CDATA[8-Hydroxy-2-(di-n-propylamino)tetralin - administration & dosage ; Analysis of Variance ; Animals ; Biological and medical sciences ; Circadian Rhythm - drug effects ; Circadian Rhythm - physiology ; Cricetinae ; fluoxetine ; Fluoxetine - administration & dosage ; Fundamental and applied biological sciences. Psychology ; Male ; Mesocricetus ; Motor Activity - drug effects ; Neurology ; Photic Stimulation ; Photoperiod ; Serotonin - metabolism ; Serotonin Agents - administration & dosage ; Serotonin Receptor Agonists - administration & dosage ; Serotonin Uptake Inhibitors - administration & dosage ; suprachiasmatic nucleus ; Syrian hamster ; Time Factors ; tryptophan ; Tryptophan - administration & dosage ; Vertebrates: nervous system and sense organs]]></subject><ispartof>Neuroscience, 2009-04, Vol.159 (4), p.1430-1440</ispartof><rights>IBRO</rights><rights>2009 IBRO</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c601t-7fe175d6c57e3e3cc712d388be027c1aafa0d980933106e2c2eb7dd8d93bb1b63</citedby><cites>FETCH-LOGICAL-c601t-7fe175d6c57e3e3cc712d388be027c1aafa0d980933106e2c2eb7dd8d93bb1b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuroscience.2009.02.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21344173$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19217929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaur, G</creatorcontrib><creatorcontrib>Thind, R</creatorcontrib><creatorcontrib>Glass, J.D</creatorcontrib><title>Brief constant light accelerates serotonergic re-entrainment to large shifts of the daily light/dark cycle</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Abstract Brief (∼2 day) constant light exposure (LLb ) in hamsters dramatically enhances circadian phase-resetting induced by the 5-HT receptor agonist, (±)-2-dipropyl-amino-8-hydroxyl-1,2,3,4-tetrahydronapthalene (8-OH-DPAT) and other nonphotic stimuli. The present study was undertaken to determine if LLb can also amplify phase-resetting responses to endogenous 5-HT and accelerate re-entrainment to large-magnitude advance and delay shifts of the light/dark (LD) cycle. First, central serotonergic activity was increased by i.p. injection of l -tryptophan±the 5-HT reuptake inhibitor fluoxetine. Hamsters under LD or exposed to LLb received vehicle or drugs during the early morning, and phase-shifts of the locomotor activity rhythm were measured after release to constant darkness. Neither drug phase-shifted animals not exposed to LLb ( P >0.5 vs. vehicle); however in animals receiving LLb, l -tryptophan with and without fluoxetine produced large phase-advance shifts (means=2.5±0.4 h and 2.6±0.2 h, respectively; both P <0.035 vs. vehicle). Next, the effects of LLb combined with 8-OH-DPAT or l -tryptophan+fluoxetine on serotonergic re-entrainment to 10 h phase-advance and phase-delay shifts of the LD cycle were assessed. In groups not exposed to LLb , vehicle controls re-entrained slowly to the advance and delay shifts (means=16±1 and 24±4 days, respectively), but those treated with 8-OH-DPAT re-entrained faster (means=11±2 and 9±2 days, respectively; both P <0.05 vs. vehicle). In groups exposed to LLb , vehicle controls re-entrained slowly to the advance and delay shifts (means=15±2 and 25±3 days, respectively); however those receiving 8-OH-DPAT rapidly re-entrained to the delay and advance shifts, with the majority (75%) requiring only 1–2 days (means=2±1 and 4±2 days, respectively; both P <0.05 vs. vehicle). Animals exposed to LLb and treated with l -tryptophan+fluoxetine also exhibited accelerated re-entrainment to a 10 h advance shift (mean=5±2 days; P <0.05 vs. vehicle). Thus through enhancing serotonergic phase-resetting, LLb facilitates rapid re-entrainment to large shifts of the LD cycle which offers a potential approach for treating circadian-related desynchronies.</description><subject>8-Hydroxy-2-(di-n-propylamino)tetralin - administration & dosage</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Circadian Rhythm - drug effects</subject><subject>Circadian Rhythm - physiology</subject><subject>Cricetinae</subject><subject>fluoxetine</subject><subject>Fluoxetine - administration & dosage</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Mesocricetus</subject><subject>Motor Activity - drug effects</subject><subject>Neurology</subject><subject>Photic Stimulation</subject><subject>Photoperiod</subject><subject>Serotonin - metabolism</subject><subject>Serotonin Agents - administration & dosage</subject><subject>Serotonin Receptor Agonists - administration & dosage</subject><subject>Serotonin Uptake Inhibitors - administration & dosage</subject><subject>suprachiasmatic nucleus</subject><subject>Syrian hamster</subject><subject>Time Factors</subject><subject>tryptophan</subject><subject>Tryptophan - administration & dosage</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhiMEokvhLyALCW5J_ZHYMYdKUD6lShwAiZvl2JNdb7N2azuV9t_jZaNSuIAvc5hn3hnPO1X1guCGYMLPto2HOYZkHHgDDcVYNpg2JfWgWpFesFp0bfuwWmGGed12lJ5UT1La4vK6lj2uToikREgqV9X2bXQwIhN8ytpnNLn1JiNtDEwQdYaEEsSQg4e4dgZFqMHnqJ3flYhyQJOOa0Bp48acUBhR3gCy2k37o9SZ1fEKmb2Z4Gn1aNRTgmdLPK2-f3j_7eJTffnl4-eLN5e14ZjkWoxARGe56QQwYMYIQi3r-wEwFYZoPWpsZY8lYwRzoIbCIKztrWTDQAbOTqvzo-71POzAml8DT-o6up2OexW0U39mvNuodbhVlHNeJIvAq0UghpsZUlY7l8pCJu0hzElxQbCURPwTpLjtORWkgK-PoCm2pQjj3TQEq4Onaqvue6oOnipMVUmV4uf3__O7dDGxAC8XQCejpzFqb1y64yhhbVumLdy7Iwdl-7cOolraWRfBZGWD-795zv-SMZPzrnS-gj2kbZijL_4qolIpUF8PV3g4QiwxJrL7wX4CjvvfDA</recordid><startdate>20090410</startdate><enddate>20090410</enddate><creator>Kaur, G</creator><creator>Thind, R</creator><creator>Glass, J.D</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090410</creationdate><title>Brief constant light accelerates serotonergic re-entrainment to large shifts of the daily light/dark cycle</title><author>Kaur, G ; Thind, R ; Glass, J.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c601t-7fe175d6c57e3e3cc712d388be027c1aafa0d980933106e2c2eb7dd8d93bb1b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>8-Hydroxy-2-(di-n-propylamino)tetralin - administration & dosage</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Circadian Rhythm - drug effects</topic><topic>Circadian Rhythm - physiology</topic><topic>Cricetinae</topic><topic>fluoxetine</topic><topic>Fluoxetine - administration & dosage</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Mesocricetus</topic><topic>Motor Activity - drug effects</topic><topic>Neurology</topic><topic>Photic Stimulation</topic><topic>Photoperiod</topic><topic>Serotonin - metabolism</topic><topic>Serotonin Agents - administration & dosage</topic><topic>Serotonin Receptor Agonists - administration & dosage</topic><topic>Serotonin Uptake Inhibitors - administration & dosage</topic><topic>suprachiasmatic nucleus</topic><topic>Syrian hamster</topic><topic>Time Factors</topic><topic>tryptophan</topic><topic>Tryptophan - administration & dosage</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaur, G</creatorcontrib><creatorcontrib>Thind, R</creatorcontrib><creatorcontrib>Glass, J.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaur, G</au><au>Thind, R</au><au>Glass, J.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brief constant light accelerates serotonergic re-entrainment to large shifts of the daily light/dark cycle</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2009-04-10</date><risdate>2009</risdate><volume>159</volume><issue>4</issue><spage>1430</spage><epage>1440</epage><pages>1430-1440</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Abstract Brief (∼2 day) constant light exposure (LLb ) in hamsters dramatically enhances circadian phase-resetting induced by the 5-HT receptor agonist, (±)-2-dipropyl-amino-8-hydroxyl-1,2,3,4-tetrahydronapthalene (8-OH-DPAT) and other nonphotic stimuli. The present study was undertaken to determine if LLb can also amplify phase-resetting responses to endogenous 5-HT and accelerate re-entrainment to large-magnitude advance and delay shifts of the light/dark (LD) cycle. First, central serotonergic activity was increased by i.p. injection of l -tryptophan±the 5-HT reuptake inhibitor fluoxetine. Hamsters under LD or exposed to LLb received vehicle or drugs during the early morning, and phase-shifts of the locomotor activity rhythm were measured after release to constant darkness. Neither drug phase-shifted animals not exposed to LLb ( P >0.5 vs. vehicle); however in animals receiving LLb, l -tryptophan with and without fluoxetine produced large phase-advance shifts (means=2.5±0.4 h and 2.6±0.2 h, respectively; both P <0.035 vs. vehicle). Next, the effects of LLb combined with 8-OH-DPAT or l -tryptophan+fluoxetine on serotonergic re-entrainment to 10 h phase-advance and phase-delay shifts of the LD cycle were assessed. In groups not exposed to LLb , vehicle controls re-entrained slowly to the advance and delay shifts (means=16±1 and 24±4 days, respectively), but those treated with 8-OH-DPAT re-entrained faster (means=11±2 and 9±2 days, respectively; both P <0.05 vs. vehicle). In groups exposed to LLb , vehicle controls re-entrained slowly to the advance and delay shifts (means=15±2 and 25±3 days, respectively); however those receiving 8-OH-DPAT rapidly re-entrained to the delay and advance shifts, with the majority (75%) requiring only 1–2 days (means=2±1 and 4±2 days, respectively; both P <0.05 vs. vehicle). Animals exposed to LLb and treated with l -tryptophan+fluoxetine also exhibited accelerated re-entrainment to a 10 h advance shift (mean=5±2 days; P <0.05 vs. vehicle). Thus through enhancing serotonergic phase-resetting, LLb facilitates rapid re-entrainment to large shifts of the LD cycle which offers a potential approach for treating circadian-related desynchronies.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>19217929</pmid><doi>10.1016/j.neuroscience.2009.02.016</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 8-Hydroxy-2-(di-n-propylamino)tetralin - administration & dosage Analysis of Variance Animals Biological and medical sciences Circadian Rhythm - drug effects Circadian Rhythm - physiology Cricetinae fluoxetine Fluoxetine - administration & dosage Fundamental and applied biological sciences. Psychology Male Mesocricetus Motor Activity - drug effects Neurology Photic Stimulation Photoperiod Serotonin - metabolism Serotonin Agents - administration & dosage Serotonin Receptor Agonists - administration & dosage Serotonin Uptake Inhibitors - administration & dosage suprachiasmatic nucleus Syrian hamster Time Factors tryptophan Tryptophan - administration & dosage Vertebrates: nervous system and sense organs |
| title | Brief constant light accelerates serotonergic re-entrainment to large shifts of the daily light/dark cycle |
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