A critical role for DAP10 and DAP12 in CD8+ T cell–mediated tissue damage in large granular lymphocyte leukemia

Large granular lymphocyte (LGL) leukemia, or LGLL, is characterized by increased numbers of circulating clonal LGL cells in association with neutropenia, anemia, rheumatoid arthritis, and pulmonary artery hypertension (PAH). Emerging evidence suggests that LGLL cells with a CD8+CD28null phenotype in...

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Veröffentlicht in:	Blood 2009-04, Vol.113 (14), p.3226-3234
Hauptverfasser:	Chen, Xianghong, Bai, Fanqi, Sokol, Lubomir, Zhou, Junmin, Ren, Amy, Painter, Jeffrey S., Liu, Jinhong, Sallman, David A., Chen, Y. Ann, Yoder, Jeffrey A., Djeu, Julie Y., Loughran, Thomas P., Epling-Burnette, Pearlie K., Wei, Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adaptor Proteins, Signal Transducing - physiology Biological and medical sciences CD28 Antigens - metabolism CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Cytotoxicity, Immunologic - genetics Endothelial Cells - immunology Endothelial Cells - pathology Extracellular Signal-Regulated MAP Kinases - metabolism Hematologic and hematopoietic diseases Humans Immunobiology K562 Cells Leukemia, Large Granular Lymphocytic - genetics Leukemia, Large Granular Lymphocytic - immunology Leukemia, Large Granular Lymphocytic - metabolism Leukemia, Large Granular Lymphocytic - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Proteins - physiology Phosphatidylinositol 3-Kinases - metabolism Pulmonary Artery - immunology Pulmonary Artery - pathology Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Receptors, Immunologic - physiology Receptors, Natural Killer Cell - metabolism Signal Transduction - genetics Tumor Cells, Cultured
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