Cyclooxygenase-2 Is Involved in the Up-Regulation of Matrix Metalloproteinase-9 in Cholangiocarcinoma Induced by Tumor Necrosis Factor-α

Matrix metalloproteinase-9 (MMP-9) is an important enzyme in tumor invasion and metastasis in malignant tumors, including cholangiocarcinoma (CC). Tumor necrosis factor-α (TNF-α), a proinflammatory cytokine, was recently reported to induce the up-regulation of MMP-9 in cultured CC cells. We examined...

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Veröffentlicht in:	The American journal of pathology 2009-03, Vol.174 (3), p.829-841
Hauptverfasser:	Itatsu, Keita, Sasaki, Motoko, Yamaguchi, Junpei, Ohira, Shusaku, Ishikawa, Akira, Ikeda, Hiroko, Sato, Yasunori, Harada, Kenichi, Zen, Yoh, Sato, Hiroshi, Ohta, Tetsuo, Nagino, Masato, Nimura, Yuji, Nakanuma, Yasuni
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Bile Duct Neoplasms - chemically induced Bile Duct Neoplasms - enzymology Bile Duct Neoplasms - genetics Bile Ducts, Intrahepatic - enzymology Bile Ducts, Intrahepatic - pathology Cholangiocarcinoma - chemically induced Cholangiocarcinoma - enzymology Cholangiocarcinoma - genetics Cholangiocarcinoma - pathology Cyclooxygenase 2 - genetics Female Humans Immunohistochemistry Lymphatic Metastasis Male Matrix Metalloproteinase 9 - genetics Middle Aged Neoplasm Staging Pathology Promoter Regions, Genetic Receptors, Prostaglandin E - physiology Regular Tumor Necrosis Factor-alpha - toxicity Up-Regulation
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