Contribution of Growth Hormone to Mammary Neoplasia
While the effects of growth hormone (GH) on longitudinal growth are well established, the observation that GH contributes to neoplastic progression is more recent. Accumulating literature implicates GH-mediated signal transduction in the development and progression of a wide range malignancies inclu...
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| Veröffentlicht in: | Journal of mammary gland biology and neoplasia 2008-03, Vol.13 (1), p.131-145 |
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| container_title | Journal of mammary gland biology and neoplasia |
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| creator | Perry, Jo K Mohankumar, Kumarasamypet M Emerald, B. Starling Mertani, Hichem C Lobie, Peter E |
| description | While the effects of growth hormone (GH) on longitudinal growth are well established, the observation that GH contributes to neoplastic progression is more recent. Accumulating literature implicates GH-mediated signal transduction in the development and progression of a wide range malignancies including breast cancer. Recently autocrine human GH been demonstrated to be an orthotopically expressed oncogene for the human mammary gland. This review will highlight recent evidence linking GH and mammary carcinoma and discuss GH-antagonism as a potential therapeutic approach for treatment of breast cancer. |
| doi_str_mv | 10.1007/s10911-008-9070-z |
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Starling</creatorcontrib><creatorcontrib>Mertani, Hichem C</creatorcontrib><creatorcontrib>Lobie, Peter E</creatorcontrib><title>Contribution of Growth Hormone to Mammary Neoplasia</title><title>Journal of mammary gland biology and neoplasia</title><addtitle>J Mammary Gland Biol Neoplasia</addtitle><addtitle>J Mammary Gland Biol Neoplasia</addtitle><description>While the effects of growth hormone (GH) on longitudinal growth are well established, the observation that GH contributes to neoplastic progression is more recent. Accumulating literature implicates GH-mediated signal transduction in the development and progression of a wide range malignancies including breast cancer. Recently autocrine human GH been demonstrated to be an orthotopically expressed oncogene for the human mammary gland. This review will highlight recent evidence linking GH and mammary carcinoma and discuss GH-antagonism as a potential therapeutic approach for treatment of breast cancer.</description><subject>Animals</subject><subject>Autocrine Communication</subject><subject>breast neoplasms</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Disease Models, Animal</subject><subject>Growth Hormone - antagonists & inhibitors</subject><subject>Growth Hormone - metabolism</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>mammary development</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Other</subject><subject>Risk Factors</subject><subject>somatotropin</subject><issn>1083-3021</issn><issn>1573-7039</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9PGzEQxS1UBCHlA3Chq944bJnxn7V9qRRFhSAFONCcLe_GmyxK1qm9SVU-fR1tRNoeevLI83tvZvQIuUL4ggDyNiJoxBxA5Rok5G8nZIBCslwC0x9SDYrlDCiek4sYXwFAq0KckXNUVDAJakDY2LddaMpt1_g283V2H_zPbplNfFj71mWdzx7tem3Dr-zJ-c3KxsZ-JKe1XUV3eXiHZHb37ft4kk-f7x_Go2lepR26fC41ryurCukcr0o755rPnQJVa0FZzSUvee00l1Wl0BUFlaUSEm0JQlcJZkPytffdbMu1m1cubWpXZhOa_T7G28b83WmbpVn4naFFIVCzZHDTGyz_kU1GU7P_A0go0mKHif18GBb8j62LnXn129Cm-wxFTbnSXCUIe6gKPsbg6ndXBLOPxPSRJGNl9pGYt6S5_vOKo-KQQQJoD8TUahcuHCf_z_VTL6qtN3YRmmhmLxSQJabgSgj2G07Cn-c</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Perry, Jo K</creator><creator>Mohankumar, Kumarasamypet M</creator><creator>Emerald, B. 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| subjects | Animals Autocrine Communication breast neoplasms Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cancer Cancer Research Cell Transformation, Neoplastic - metabolism Disease Models, Animal Growth Hormone - antagonists & inhibitors Growth Hormone - metabolism Humans Life Sciences mammary development Medicine Medicine & Public Health Oncology Other Risk Factors somatotropin |
| title | Contribution of Growth Hormone to Mammary Neoplasia |
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