The MurC Ligase Essential for Peptidoglycan Biosynthesis Is Regulated by the Serine/Threonine Protein Kinase PknA in Corynebacterium glutamicum

The Mur ligases play an essential role in the biosynthesis of bacterial cell-wall peptidoglycan and thus represent attractive targets for the design of novel antibacterials. These enzymes catalyze the stepwise formation of the peptide moiety of the peptidoglycan disaccharide peptide monomer unit. Mu...

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Veröffentlicht in:	The Journal of biological chemistry 2008-12, Vol.283 (52), p.36553-36563
Hauptverfasser:	Fiuza, Maria, Canova, Marc J., Patin, Delphine, Letek, Michal, Zanella-Cléon, Isabelle, Becchi, Michel, Mateos, Luís M., Mengin-Lecreulx, Dominique, Molle, Virginie, Gil, José A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - chemistry Amino Acid Sequence Bacterial Proteins - metabolism Bacteriology DNA Primers - chemistry Gene Expression Regulation, Bacterial Life Sciences Ligases - metabolism Ligases - physiology Microbiology and Parasitology Models, Biological Molecular Sequence Data Peptide Synthases - biosynthesis Peptide Synthases - physiology Peptidoglycan - chemistry Phosphoamino Acids - chemistry Phosphorylation Plasmids - metabolism Protein Isoforms Protein Structure, Tertiary Protein Synthesis, Post-Translational Modification, and Degradation Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - physiology Sequence Homology, Amino Acid
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