The Third Intracellular Loop Stabilizes the Inactive State of the Neuropeptide Y1 Receptor

Constitutively active G-protein-coupled receptors (GPCRs) can signal even in the absence of ligand binding. Most Class I GPCRs are stabilized in the resting conformation by intramolecular interactions involving transmembrane domain (TM) 3 and TM6, particularly at loci 6.30 and 6.34 of TM6. Signaling...

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Veröffentlicht in:	The Journal of biological chemistry 2008-11, Vol.283 (48), p.33337-33346
Hauptverfasser:	Chee, Melissa J.S., Mörl, Karin, Lindner, Diana, Merten, Nicole, Zamponi, Gerald W., Light, Peter E., Beck-Sickinger, Annette G., Colmers, William F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chlorocebus aethiops COS Cells GTP-Binding Protein alpha Subunits, Gi-Go - genetics GTP-Binding Protein alpha Subunits, Gi-Go - metabolism GTP-Binding Protein alpha Subunits, Gq-G11 - genetics GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism Humans Mechanisms of Signal Transduction Point Mutation Protein Structure, Secondary - physiology Protein Structure, Tertiary - physiology Receptors, Neuropeptide Y - genetics Receptors, Neuropeptide Y - metabolism Receptors, Opioid, mu - genetics Receptors, Opioid, mu - metabolism Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2Y12 Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Signal Transduction - physiology
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