Experimental Investigation of the Seesaw Mechanism of the Relay Region That Moves the Myosin Lever Arm

A seesaw-like movement of the relay region upon the recovery step of myosin was recently simulated in silico. In this model the relay helix tilts around its pivoting point formed by a phenylalanine cluster (Phe481, Phe482, and Phe652), which moves the lever arm of myosin. To study the effect of the...

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Veröffentlicht in:	The Journal of biological chemistry 2008-12, Vol.283 (49), p.34121-34128
Hauptverfasser:	Kintses, Bálint, Yang, Zhenhui, Málnási-Csizmadia, András
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - chemistry Adenosine Triphosphate - chemistry Animals Binding Sites Dictyostelium Hydrolysis Kinetics Mutation Myosin Type II - chemistry Myosin Type II - physiology Nucleotides - chemistry Protein Binding Protein Conformation Protein Structure and Folding Spectrometry, Fluorescence - methods Thermodynamics Tryptophan - chemistry
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