Tumor Necrosis Factor Receptor-associated Factor 6 Is an Intranuclear Transcriptional Coactivator in Osteoclasts

Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with the cytoplasmic domain of receptor activator of NF-κB (RANK) and is an essential component of the signaling complex mediating osteoclastogenesis. However, the osteoclastic activity of TRAF6 is blunted by its association with...

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Veröffentlicht in:	The Journal of biological chemistry 2008-11, Vol.283 (45), p.30861-30867
Hauptverfasser:	Bai, Shuting, Zha, Jikun, Zhao, Haibo, Ross, F. Patrick, Teitelbaum, Steven L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Nucleus - genetics Cell Nucleus - metabolism Chlorocebus aethiops Core Binding Factor Alpha 2 Subunit - genetics Core Binding Factor Alpha 2 Subunit - metabolism COS Cells Cytoplasm - genetics Cytoplasm - metabolism Gene Expression Regulation - physiology Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans LIM-Homeodomain Proteins Mice Molecular Basis of Cell and Developmental Biology Monocyte-Macrophage Precursor Cells - cytology Monocyte-Macrophage Precursor Cells - metabolism Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Muscle Proteins - genetics Muscle Proteins - metabolism Osteoclasts - cytology Osteoclasts - metabolism Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism RANK Ligand - genetics RANK Ligand - metabolism Receptor Activator of Nuclear Factor-kappa B - genetics Receptor Activator of Nuclear Factor-kappa B - metabolism Response Elements - physiology Signal Transduction - physiology TNF Receptor-Associated Factor 6 - genetics TNF Receptor-Associated Factor 6 - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - physiology Ubiquitination - physiology
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