Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling

Signaling through mammalian target of rapamycin complex 1 (mTORC1) is stimulated by amino acids and insulin. Insulin inactivates TSC1/2, the GTPase-activator complex for Rheb, and Rheb·GTP activates mTORC1. It is not clear how amino acids regulate mTORC1. FKBP38 (immunophilin FK506-binding protein,...

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Veröffentlicht in:	The Journal of biological chemistry 2008-11, Vol.283 (45), p.30482-30492
Hauptverfasser:	Wang, Xuemin, Fonseca, Bruno D., Tang, Hua, Liu, Rui, Elia, Androulla, Clemens, Michael J., Bommer, Ulrich-Axel, Proud, Christopher G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - metabolism Amino Acids - pharmacology Animals Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism CHO Cells Cricetinae Cricetulus Humans Hypoglycemic Agents - metabolism Hypoglycemic Agents - pharmacology Insulin - metabolism Insulin - pharmacology Leucine-tRNA Ligase - genetics Leucine-tRNA Ligase - metabolism Mechanisms of Signal Transduction Mechanistic Target of Rapamycin Complex 1 Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Mutation Neuropeptides - genetics Neuropeptides - metabolism Protein Binding - physiology Proteins Ras Homolog Enriched in Brain Protein RNA, Transfer - genetics RNA, Transfer - metabolism Signal Transduction - physiology Tacrolimus Binding Proteins - genetics Tacrolimus Binding Proteins - metabolism Telomerase - genetics Telomerase - metabolism TOR Serine-Threonine Kinases Transcription Factors - genetics Transcription Factors - metabolism Tuberous Sclerosis Complex 2 Protein Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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