Foxo3a Inhibits Cardiomyocyte Hypertrophy through Transactivating Catalase

The forkhead transcription factor Foxo3a is able to inhibit cardiomyocyte hypertrophy. However, its underlying molecular mechanism remains to be fully understood. Our present study demonstrates that Foxo3a can regulate cardiomyocyte hypertrophy through transactivating catalase. Insulin was able to i...

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Veröffentlicht in:	The Journal of biological chemistry 2008-10, Vol.283 (44), p.29730-29739
Hauptverfasser:	Tan, Wei-Qi, Wang, Kun, Lv, Dao-Yuan, Li, Pei-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catalase - metabolism Forkhead Box Protein O3 Forkhead Transcription Factors - metabolism Forkhead Transcription Factors - physiology Gene Expression Regulation, Enzymologic Humans Hypertrophy Insulin-Like Growth Factor I - metabolism Metabolism and Bioenergetics Models, Biological Myocytes, Cardiac - metabolism Nuclear Proteins - metabolism Rats Rats, Wistar Reactive Oxygen Species Trans-Activators - metabolism Transcriptional Activation
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