Manganese Neurotoxicity: Lessons Learned from Longitudinal Studies in Nonhuman Primates

Background: Exposure to excess levels of the essential trace element manganese produces cognitive, psychiatric, and motor abnormalities. The understanding of Mn neurotoxicology is heavily governed by pathologic and neurochemical observations derived from rodent studies that often employ acute Mn exp...

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Veröffentlicht in:	Environmental health perspectives 2009-03, Vol.117 (3), p.325-332
Hauptverfasser:	Burton, Neal C., Guilarte, Tomás R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Astrocytes Beta Biocompatibility Biomedical materials Brain Chemical hazards Cognition Cognition - drug effects Cortexes Creatine - metabolism Cynomolgus Diagnosis Dopamine Environmental aspects Environmental Exposure Environmental health Gene expression Globus pallidus Glutamate-Ammonia Ligase - metabolism Health Health aspects In vivo testing In vivo tests Kinetics Macaca Magnetic resonance Manganese Manganese - toxicity Markers Mitochondria - drug effects Mitochondria - metabolism Monkeys Motor Activity - drug effects Motors Nervous System - drug effects Nervous system diseases Neuroimaging Neurons Neurotoxicity Neurotransmitter Agents - metabolism Neurotransmitters Oxidative Stress - drug effects Primates Review Reviews Risk factors Rodents Surgical implants Synapses - drug effects
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