Transferrin-a modulates hepcidin expression in zebrafish embryos

The iron regulatory hormone hepcidin is transcriptionally up-regulated in response to iron loading, but the mechanisms by which iron levels are sensed are not well understood. Large-scale genetic screens in the zebrafish have resulted in the identification of hypochromic anemia mutants with a range...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 2009-03, Vol.113 (12), p.2843-2850
Hauptverfasser:	Fraenkel, Paula G., Gibert, Yann, Holzheimer, Jason L., Lattanzi, Victoria J., Burnett, Sarah F., Dooley, Kimberly A., Wingert, Rebecca A., Zon, Leonard I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anemia, Hypochromic - chemically induced Anemia, Hypochromic - embryology Anemia, Hypochromic - genetics Animals Antimicrobial Cationic Peptides - biosynthesis Antimicrobial Cationic Peptides - genetics Biological and medical sciences Cation Transport Proteins - genetics Embryo, Nonmammalian - drug effects Embryo, Nonmammalian - metabolism Erythropoiesis - drug effects Erythropoiesis - genetics Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - physiology Gene Knockdown Techniques Hematologic and hematopoietic diseases Hepcidins - biosynthesis Hepcidins - deficiency Hepcidins - genetics Hepcidins - physiology Humans Iron - metabolism Iron - pharmacology Medical sciences Molecular Sequence Data Mutation Organ Specificity Phenylhydrazines - toxicity Receptors, Transferrin - antagonists & inhibitors Receptors, Transferrin - genetics Receptors, Transferrin - physiology Red Cells, Iron, and Erythropoiesis Sequence Alignment Sequence Homology, Amino Acid Species Specificity Transferrin - deficiency Transferrin - genetics Transferrin - physiology Zebrafish - embryology Zebrafish Proteins - biosynthesis Zebrafish Proteins - deficiency Zebrafish Proteins - genetics Zebrafish Proteins - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!