Spontaneous preterm birth and small for gestational age infants in women who stop smoking early in pregnancy: prospective cohort study
Objectives To compare pregnancy outcomes between women who stopped smoking in early pregnancy and those who either did not smoke in pregnancy or continued to smoke.Design Prospective cohort study.Setting Auckland, New Zealand and Adelaide, Australia.Participants 2504 nulliparous women participating...
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| Veröffentlicht in: | BMJ 2009-03, Vol.338 (7710), p.1552-1552 |
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| creator | McCowan, Lesley M E Dekker, Gustaaf A Chan, Eliza Stewart, Alistair Chappell, Lucy C Hunter, Misty Moss-Morris, Rona North, Robyn A |
| description | Objectives To compare pregnancy outcomes between women who stopped smoking in early pregnancy and those who either did not smoke in pregnancy or continued to smoke.Design Prospective cohort study.Setting Auckland, New Zealand and Adelaide, Australia.Participants 2504 nulliparous women participating in the Screening for Pregnancy Endpoints (SCOPE) study grouped by maternal smoking status at 15 (±1) week’s gestation.Main outcome measures Spontaneous preterm birth and small for gestational age infants (birth weight |
| doi_str_mv | 10.1136/bmj.b1081 |
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| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2661373</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>25671924</jstor_id><sourcerecordid>25671924</sourcerecordid><originalsourceid>FETCH-LOGICAL-b645t-e308e8e30ab019097d264976f197cf07e121d697c1d906c6eb8f8694524a5b13</originalsourceid><addsrcrecordid>eNp9kttu1DAQhiMEolXpBQ8AsigHcZHiQ3wIF0hogYJUgRAVt5aTOLvZJnawvYV9AZ6bCVltAancjC3938zY_0yW3Sf4lBAmXlTD-rQiWJFb2SEphMq5Yux2dohLXuaKMHWQHce4xhhTJlUp-N3sgJSMciLlYfbzy-hdMs76TURjsMmGAVVdSCtkXIPiYPoetT6gpY3JpM470yOztKhzrXEpwom--8FCXHkUkx8hx192bomsCf120qHs0hlXb1_C1cfR1qm7sqj2Kx8S5Gya7b3sTmv6aI9351F28e7txeJ9fv7p7MPi9XleiYKn3DKsrIJoKkxKXMqGiqKUoiWlrFssLaGkEXAnTYlFLWylWiXKgtPC8Iqwo-zVXHbcVINtautSML0eQzeYsNXedPpvxXUrvfRXmgpBmGRQ4NmuQPDfNmCJHrpY276fHdRSFEwpXlAgn_6XFBJLJTEG8NE_4NpvAtgcNcUFppjjqe_JTRCMUeGCSayAej5TNdgcg233PyNYT8uiYVn072UB9uGfVlyTu9UA4MkOMLE2fRtggl3cc5RwQRmdmj6YuTVMP1zrXEhS0gL0fNa7mOyPvW7CJXjAJNcfvy60enOG8eeC6Mm4xzM_vfXm9_8CkPDsnA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1778043708</pqid></control><display><type>article</type><title>Spontaneous preterm birth and small for gestational age infants in women who stop smoking early in pregnancy: prospective cohort study</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Jstor Complete Legacy</source><source>BMJ Journals Online Archive</source><source>MEDLINE</source><creator>McCowan, Lesley M E ; Dekker, Gustaaf A ; Chan, Eliza ; Stewart, Alistair ; Chappell, Lucy C ; Hunter, Misty ; Moss-Morris, Rona ; North, Robyn A</creator><creatorcontrib>McCowan, Lesley M E ; Dekker, Gustaaf A ; Chan, Eliza ; Stewart, Alistair ; Chappell, Lucy C ; Hunter, Misty ; Moss-Morris, Rona ; North, Robyn A ; SCOPE consortium ; On behalf of the SCOPE consortium</creatorcontrib><description>Objectives To compare pregnancy outcomes between women who stopped smoking in early pregnancy and those who either did not smoke in pregnancy or continued to smoke.Design Prospective cohort study.Setting Auckland, New Zealand and Adelaide, Australia.Participants 2504 nulliparous women participating in the Screening for Pregnancy Endpoints (SCOPE) study grouped by maternal smoking status at 15 (±1) week’s gestation.Main outcome measures Spontaneous preterm birth and small for gestational age infants (birth weight <10th customised centile). We compared odds of these outcomes between stopped smokers and non-smokers, and between current smokers and stopped smokers, using logistic regression, adjusting for demographic and clinical risk factors.Results 80% (n=1992) of women were non-smokers, 10% (n=261) had stopped smoking, and 10% (n=251) were current smokers. We noted no differences in rates of spontaneous preterm birth (4%, n=88 v 4%, n=10; adjusted odds ratio 1.03, 95% confidence interval l0.49 to 2.18; P=0.66) or small for gestational age infants (10%, n=195 v 10%, n=27; 1.06, 0.67 to 1.68; P=0.8) between non-smokers and stopped smokers. Current smokers had higher rates of spontaneous preterm birth (10%, n=25 v 4%, n=10; 3.21, 1.42 to 7.23; P=0.006) and small for gestational age infants (17%, n=42 v 10%, n=27; 1.76, 1.03 to 3.02; P=0.03) than stopped smokers.Conclusion In women who stopped smoking before 15 weeks’ gestation, rates of spontaneous preterm birth and small for gestational age infants did not differ from those in non-smokers, indicating that these severe adverse effects of smoking may be reversible if smoking is stopped early in pregnancy.</description><edition>International edition</edition><identifier>ISSN: 0959-8138</identifier><identifier>ISSN: 0959-8146</identifier><identifier>ISSN: 1756-1833</identifier><identifier>EISSN: 1468-5833</identifier><identifier>EISSN: 1756-1833</identifier><identifier>DOI: 10.1136/bmj.b1081</identifier><identifier>PMID: 19325177</identifier><identifier>CODEN: BMJOAE</identifier><language>eng</language><publisher>London: British Medical Journal Publishing Group</publisher><subject>Adult ; Anxiety ; Babies ; Biological and medical sciences ; Birth weight ; Blood pressure ; Child Health ; Clinical outcomes ; Cohort analysis ; Cohort studies ; Creatinine ; Diseases of mother, fetus and pregnancy ; Epidemiologic Studies ; Female ; General aspects ; Gestational age ; Gynecology. Andrology. Obstetrics ; Health care ; Health Education ; Health Promotion ; Humans ; Infant, Newborn ; Infant, Small for Gestational Age ; Infants ; Medical sciences ; Menstruation ; Midwifery ; Minority & ethnic groups ; Miscarriage ; Preeclampsia ; Pregnancy ; Pregnancy complications ; Pregnancy Outcome ; Pregnancy Trimester, First ; Pregnancy. Fetus. Placenta ; Premature birth ; Premature Birth - etiology ; Prospective Studies ; Proteins ; Questionnaires ; Regression analysis ; Reproductive Medicine ; Risk factors ; Screening (Epidemiology) ; Screening (Public Health) ; Small for gestational age ; Smoking ; Smoking - adverse effects ; Smoking and Tobacco ; Smoking Cessation ; Tobacco, tobacco smoking ; Toxicology ; Womens health</subject><ispartof>BMJ, 2009-03, Vol.338 (7710), p.1552-1552</ispartof><rights>McCowan et al 2009</rights><rights>2009 BMJ Publishing Group Ltd</rights><rights>2009 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Mar 26, 2009</rights><rights>Copyright BMJ Publishing Group Jun 27, 2009</rights><rights>McCowan et al 2009 2009 McCowan et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b645t-e308e8e30ab019097d264976f197cf07e121d697c1d906c6eb8f8694524a5b13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bmj.com/content/338/bmj.b1081.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttp://bmj.com/content/338/bmj.b1081.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>114,115,230,314,776,780,799,881,3183,23550,27901,27902,30976,57992,58225,77342,77373</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21562328$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19325177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McCowan, Lesley M E</creatorcontrib><creatorcontrib>Dekker, Gustaaf A</creatorcontrib><creatorcontrib>Chan, Eliza</creatorcontrib><creatorcontrib>Stewart, Alistair</creatorcontrib><creatorcontrib>Chappell, Lucy C</creatorcontrib><creatorcontrib>Hunter, Misty</creatorcontrib><creatorcontrib>Moss-Morris, Rona</creatorcontrib><creatorcontrib>North, Robyn A</creatorcontrib><creatorcontrib>SCOPE consortium</creatorcontrib><creatorcontrib>On behalf of the SCOPE consortium</creatorcontrib><title>Spontaneous preterm birth and small for gestational age infants in women who stop smoking early in pregnancy: prospective cohort study</title><title>BMJ</title><addtitle>BMJ</addtitle><description>Objectives To compare pregnancy outcomes between women who stopped smoking in early pregnancy and those who either did not smoke in pregnancy or continued to smoke.Design Prospective cohort study.Setting Auckland, New Zealand and Adelaide, Australia.Participants 2504 nulliparous women participating in the Screening for Pregnancy Endpoints (SCOPE) study grouped by maternal smoking status at 15 (±1) week’s gestation.Main outcome measures Spontaneous preterm birth and small for gestational age infants (birth weight <10th customised centile). We compared odds of these outcomes between stopped smokers and non-smokers, and between current smokers and stopped smokers, using logistic regression, adjusting for demographic and clinical risk factors.Results 80% (n=1992) of women were non-smokers, 10% (n=261) had stopped smoking, and 10% (n=251) were current smokers. We noted no differences in rates of spontaneous preterm birth (4%, n=88 v 4%, n=10; adjusted odds ratio 1.03, 95% confidence interval l0.49 to 2.18; P=0.66) or small for gestational age infants (10%, n=195 v 10%, n=27; 1.06, 0.67 to 1.68; P=0.8) between non-smokers and stopped smokers. Current smokers had higher rates of spontaneous preterm birth (10%, n=25 v 4%, n=10; 3.21, 1.42 to 7.23; P=0.006) and small for gestational age infants (17%, n=42 v 10%, n=27; 1.76, 1.03 to 3.02; P=0.03) than stopped smokers.Conclusion In women who stopped smoking before 15 weeks’ gestation, rates of spontaneous preterm birth and small for gestational age infants did not differ from those in non-smokers, indicating that these severe adverse effects of smoking may be reversible if smoking is stopped early in pregnancy.</description><subject>Adult</subject><subject>Anxiety</subject><subject>Babies</subject><subject>Biological and medical sciences</subject><subject>Birth weight</subject><subject>Blood pressure</subject><subject>Child Health</subject><subject>Clinical outcomes</subject><subject>Cohort analysis</subject><subject>Cohort studies</subject><subject>Creatinine</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Epidemiologic Studies</subject><subject>Female</subject><subject>General aspects</subject><subject>Gestational age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Health care</subject><subject>Health Education</subject><subject>Health Promotion</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Small for Gestational Age</subject><subject>Infants</subject><subject>Medical sciences</subject><subject>Menstruation</subject><subject>Midwifery</subject><subject>Minority & ethnic groups</subject><subject>Miscarriage</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Premature birth</subject><subject>Premature Birth - etiology</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Reproductive Medicine</subject><subject>Risk factors</subject><subject>Screening (Epidemiology)</subject><subject>Screening (Public Health)</subject><subject>Small for gestational age</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Smoking and Tobacco</subject><subject>Smoking Cessation</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><subject>Womens health</subject><issn>0959-8138</issn><issn>0959-8146</issn><issn>1756-1833</issn><issn>1468-5833</issn><issn>1756-1833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>7QJ</sourceid><recordid>eNp9kttu1DAQhiMEolXpBQ8AsigHcZHiQ3wIF0hogYJUgRAVt5aTOLvZJnawvYV9AZ6bCVltAancjC3938zY_0yW3Sf4lBAmXlTD-rQiWJFb2SEphMq5Yux2dohLXuaKMHWQHce4xhhTJlUp-N3sgJSMciLlYfbzy-hdMs76TURjsMmGAVVdSCtkXIPiYPoetT6gpY3JpM470yOztKhzrXEpwom--8FCXHkUkx8hx192bomsCf120qHs0hlXb1_C1cfR1qm7sqj2Kx8S5Gya7b3sTmv6aI9351F28e7txeJ9fv7p7MPi9XleiYKn3DKsrIJoKkxKXMqGiqKUoiWlrFssLaGkEXAnTYlFLWylWiXKgtPC8Iqwo-zVXHbcVINtautSML0eQzeYsNXedPpvxXUrvfRXmgpBmGRQ4NmuQPDfNmCJHrpY276fHdRSFEwpXlAgn_6XFBJLJTEG8NE_4NpvAtgcNcUFppjjqe_JTRCMUeGCSayAej5TNdgcg233PyNYT8uiYVn072UB9uGfVlyTu9UA4MkOMLE2fRtggl3cc5RwQRmdmj6YuTVMP1zrXEhS0gL0fNa7mOyPvW7CJXjAJNcfvy60enOG8eeC6Mm4xzM_vfXm9_8CkPDsnA</recordid><startdate>20090326</startdate><enddate>20090326</enddate><creator>McCowan, Lesley M E</creator><creator>Dekker, Gustaaf A</creator><creator>Chan, Eliza</creator><creator>Stewart, Alistair</creator><creator>Chappell, Lucy C</creator><creator>Hunter, Misty</creator><creator>Moss-Morris, Rona</creator><creator>North, Robyn A</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group Ltd</general><scope>9YT</scope><scope>ACMMV</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QJ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090326</creationdate><title>Spontaneous preterm birth and small for gestational age infants in women who stop smoking early in pregnancy: prospective cohort study</title><author>McCowan, Lesley M E ; Dekker, Gustaaf A ; Chan, Eliza ; Stewart, Alistair ; Chappell, Lucy C ; Hunter, Misty ; Moss-Morris, Rona ; North, Robyn A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b645t-e308e8e30ab019097d264976f197cf07e121d697c1d906c6eb8f8694524a5b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Anxiety</topic><topic>Babies</topic><topic>Biological and medical sciences</topic><topic>Birth weight</topic><topic>Blood pressure</topic><topic>Child Health</topic><topic>Clinical outcomes</topic><topic>Cohort analysis</topic><topic>Cohort studies</topic><topic>Creatinine</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Epidemiologic Studies</topic><topic>Female</topic><topic>General aspects</topic><topic>Gestational age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Health care</topic><topic>Health Education</topic><topic>Health Promotion</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Small for Gestational Age</topic><topic>Infants</topic><topic>Medical sciences</topic><topic>Menstruation</topic><topic>Midwifery</topic><topic>Minority & ethnic groups</topic><topic>Miscarriage</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Premature birth</topic><topic>Premature Birth - etiology</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Questionnaires</topic><topic>Regression analysis</topic><topic>Reproductive Medicine</topic><topic>Risk factors</topic><topic>Screening (Epidemiology)</topic><topic>Screening (Public Health)</topic><topic>Small for gestational age</topic><topic>Smoking</topic><topic>Smoking - adverse effects</topic><topic>Smoking and Tobacco</topic><topic>Smoking Cessation</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCowan, Lesley M E</creatorcontrib><creatorcontrib>Dekker, Gustaaf A</creatorcontrib><creatorcontrib>Chan, Eliza</creatorcontrib><creatorcontrib>Stewart, Alistair</creatorcontrib><creatorcontrib>Chappell, Lucy C</creatorcontrib><creatorcontrib>Hunter, Misty</creatorcontrib><creatorcontrib>Moss-Morris, Rona</creatorcontrib><creatorcontrib>North, Robyn A</creatorcontrib><creatorcontrib>SCOPE consortium</creatorcontrib><creatorcontrib>On behalf of the SCOPE consortium</creatorcontrib><collection>BMJ Journals (Open Access)</collection><collection>BMJ Journals:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>ProQuest research library</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCowan, Lesley M E</au><au>Dekker, Gustaaf A</au><au>Chan, Eliza</au><au>Stewart, Alistair</au><au>Chappell, Lucy C</au><au>Hunter, Misty</au><au>Moss-Morris, Rona</au><au>North, Robyn A</au><aucorp>SCOPE consortium</aucorp><aucorp>On behalf of the SCOPE consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous preterm birth and small for gestational age infants in women who stop smoking early in pregnancy: prospective cohort study</atitle><jtitle>BMJ</jtitle><addtitle>BMJ</addtitle><date>2009-03-26</date><risdate>2009</risdate><volume>338</volume><issue>7710</issue><spage>1552</spage><epage>1552</epage><pages>1552-1552</pages><issn>0959-8138</issn><issn>0959-8146</issn><issn>1756-1833</issn><eissn>1468-5833</eissn><eissn>1756-1833</eissn><coden>BMJOAE</coden><abstract>Objectives To compare pregnancy outcomes between women who stopped smoking in early pregnancy and those who either did not smoke in pregnancy or continued to smoke.Design Prospective cohort study.Setting Auckland, New Zealand and Adelaide, Australia.Participants 2504 nulliparous women participating in the Screening for Pregnancy Endpoints (SCOPE) study grouped by maternal smoking status at 15 (±1) week’s gestation.Main outcome measures Spontaneous preterm birth and small for gestational age infants (birth weight <10th customised centile). We compared odds of these outcomes between stopped smokers and non-smokers, and between current smokers and stopped smokers, using logistic regression, adjusting for demographic and clinical risk factors.Results 80% (n=1992) of women were non-smokers, 10% (n=261) had stopped smoking, and 10% (n=251) were current smokers. We noted no differences in rates of spontaneous preterm birth (4%, n=88 v 4%, n=10; adjusted odds ratio 1.03, 95% confidence interval l0.49 to 2.18; P=0.66) or small for gestational age infants (10%, n=195 v 10%, n=27; 1.06, 0.67 to 1.68; P=0.8) between non-smokers and stopped smokers. Current smokers had higher rates of spontaneous preterm birth (10%, n=25 v 4%, n=10; 3.21, 1.42 to 7.23; P=0.006) and small for gestational age infants (17%, n=42 v 10%, n=27; 1.76, 1.03 to 3.02; P=0.03) than stopped smokers.Conclusion In women who stopped smoking before 15 weeks’ gestation, rates of spontaneous preterm birth and small for gestational age infants did not differ from those in non-smokers, indicating that these severe adverse effects of smoking may be reversible if smoking is stopped early in pregnancy.</abstract><cop>London</cop><pub>British Medical Journal Publishing Group</pub><pmid>19325177</pmid><doi>10.1136/bmj.b1081</doi><tpages>1</tpages><edition>International edition</edition><oa>free_for_read</oa></addata></record> |
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| ispartof | BMJ, 2009-03, Vol.338 (7710), p.1552-1552 |
| issn | 0959-8138 0959-8146 1756-1833 1468-5833 1756-1833 |
| language | eng |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); Jstor Complete Legacy; BMJ Journals Online Archive; MEDLINE |
| subjects | Adult Anxiety Babies Biological and medical sciences Birth weight Blood pressure Child Health Clinical outcomes Cohort analysis Cohort studies Creatinine Diseases of mother, fetus and pregnancy Epidemiologic Studies Female General aspects Gestational age Gynecology. Andrology. Obstetrics Health care Health Education Health Promotion Humans Infant, Newborn Infant, Small for Gestational Age Infants Medical sciences Menstruation Midwifery Minority & ethnic groups Miscarriage Preeclampsia Pregnancy Pregnancy complications Pregnancy Outcome Pregnancy Trimester, First Pregnancy. Fetus. Placenta Premature birth Premature Birth - etiology Prospective Studies Proteins Questionnaires Regression analysis Reproductive Medicine Risk factors Screening (Epidemiology) Screening (Public Health) Small for gestational age Smoking Smoking - adverse effects Smoking and Tobacco Smoking Cessation Tobacco, tobacco smoking Toxicology Womens health |
| title | Spontaneous preterm birth and small for gestational age infants in women who stop smoking early in pregnancy: prospective cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T00%3A54%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Spontaneous%20preterm%20birth%20and%20small%20for%20gestational%20age%20infants%20in%20women%20who%20stop%20smoking%20early%20in%20pregnancy:%20prospective%20cohort%20study&rft.jtitle=BMJ&rft.au=McCowan,%20Lesley%20M%20E&rft.aucorp=SCOPE%20consortium&rft.date=2009-03-26&rft.volume=338&rft.issue=7710&rft.spage=1552&rft.epage=1552&rft.pages=1552-1552&rft.issn=0959-8138&rft.eissn=1468-5833&rft.coden=BMJOAE&rft_id=info:doi/10.1136/bmj.b1081&rft_dat=%3Cjstor_pubme%3E25671924%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1778043708&rft_id=info:pmid/19325177&rft_jstor_id=25671924&rfr_iscdi=true |