Cytosolic Protein Response as a Subcomponent of the Wider Heat Shock Response in Arabidopsis
In common with a range of environmental and biological stresses, heat shock results in the accumulation of misfolded proteins and a collection of downstream consequences for cellular homeostasis and growth. Within this complex array of responses, the sensing of and responses to misfolded proteins in...
Gespeichert in:
| Veröffentlicht in: | The Plant cell 2009-02, Vol.21 (2), p.642-654 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 654 |
|---|---|
| container_issue | 2 |
| container_start_page | 642 |
| container_title | The Plant cell |
| container_volume | 21 |
| creator | Sugio, Akiko Dreos, René Aparicio, Frederic Maule, Andrew J |
| description | In common with a range of environmental and biological stresses, heat shock results in the accumulation of misfolded proteins and a collection of downstream consequences for cellular homeostasis and growth. Within this complex array of responses, the sensing of and responses to misfolded proteins in specific subcellular compartments involves specific chaperones, transcriptional regulators, and expression profiles. Using biological (ectopic protein expression and virus infection) and chemical triggers for misfolded protein accumulation, we have profiled the transcriptional features of the response to misfolded protein accumulation in the cytosol (i.e., the cytoplasmic protein response [CPR]) and identified the effects as a subcomponent of the wider effects induced by heat shock. The CPR in Arabidopsis thaliana is associated with the heat shock promoter element and the involvement of specific heat shock factors (HSFs), notably HSFA2, which appears to be regulated by alternative splicing and non-sense-mediated decay. Characterization of Arabidopsis HSFA2 knockout and overexpression lines showed that HSFA2 is one of the regulatory components of the CPR. |
| doi_str_mv | 10.1105/tpc.108.062596 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2660624</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>40537417</jstor_id><sourcerecordid>40537417</sourcerecordid><originalsourceid>FETCH-LOGICAL-c493t-fa5ba5a362fc781dbf4b634e79e64eead6d76cb47bbf5b24fb11ed81a9a3003b3</originalsourceid><addsrcrecordid>eNpdkUFv1DAQhSMEoqVw5QZYPXDLMmM7TnJBqlaFVqoEYqnggGTZjtP1ko2D7SD13-MqqxY4eeT3vdGzX1G8RFghQvUuTWaF0KxA0KoVj4pjrBgtadt8f5xn4FByUeFR8SzGHQBgje3T4ghbyjlyPC5-rG-Tj35whnwOPlk3ki82Tn6MlqhIFNnM2vh9vrBjIr4naWvJN9fZQC6sSmSz9ebngyXbz4LSrvNTdPF58aRXQ7QvDudJcf3h_Ov6orz69PFyfXZVGt6yVPaq0qpSTNDe1A12uudaMG7r1gpurepEVwujea11X2nKe41ouwZVqxgA0-ykeL_snWa9t53JUYMa5BTcXoVb6ZWT_yqj28ob_1tSIfLH8bzg7WFB8L9mG5Pcu2jsMKjR-jlKUUPLeYsZPP0P3Pk5jPlxkmLTAKMcMrRaIBN8jMH290kQ5F1rMreW50YurWXD67_zP-CHmjLwagF2Mflwr3OoWM2xzvqbRe-Vl-omuCivNxSQAQrkQIH9AQGop9M</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218803240</pqid></control><display><type>article</type><title>Cytosolic Protein Response as a Subcomponent of the Wider Heat Shock Response in Arabidopsis</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Jstor Complete Legacy</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Sugio, Akiko ; Dreos, René ; Aparicio, Frederic ; Maule, Andrew J</creator><creatorcontrib>Sugio, Akiko ; Dreos, René ; Aparicio, Frederic ; Maule, Andrew J</creatorcontrib><description>In common with a range of environmental and biological stresses, heat shock results in the accumulation of misfolded proteins and a collection of downstream consequences for cellular homeostasis and growth. Within this complex array of responses, the sensing of and responses to misfolded proteins in specific subcellular compartments involves specific chaperones, transcriptional regulators, and expression profiles. Using biological (ectopic protein expression and virus infection) and chemical triggers for misfolded protein accumulation, we have profiled the transcriptional features of the response to misfolded protein accumulation in the cytosol (i.e., the cytoplasmic protein response [CPR]) and identified the effects as a subcomponent of the wider effects induced by heat shock. The CPR in Arabidopsis thaliana is associated with the heat shock promoter element and the involvement of specific heat shock factors (HSFs), notably HSFA2, which appears to be regulated by alternative splicing and non-sense-mediated decay. Characterization of Arabidopsis HSFA2 knockout and overexpression lines showed that HSFA2 is one of the regulatory components of the CPR.</description><identifier>ISSN: 1040-4651</identifier><identifier>EISSN: 1532-298X</identifier><identifier>DOI: 10.1105/tpc.108.062596</identifier><identifier>PMID: 19244141</identifier><language>eng</language><publisher>United States: American Society of Plant Biologists</publisher><subject>Accumulation ; Alternative Splicing ; Arabidopsis - drug effects ; Arabidopsis - metabolism ; Arabidopsis - physiology ; Arabidopsis Proteins ; Azetidinecarboxylic Acid - pharmacology ; Biological stress ; Cytosol - metabolism ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; DNA-Binding Proteins - physiology ; Gene Expression Profiling ; Gene expression regulation ; Genes ; Heat shock response ; Heat Shock Transcription Factors ; Heat-Shock Proteins - genetics ; Heat-Shock Proteins - metabolism ; Heat-Shock Proteins - physiology ; Heat-Shock Response - physiology ; Misfolded proteins ; Plant cells ; Plant Proteins - genetics ; Plant Proteins - metabolism ; Plant Proteins - physiology ; Promoter Regions, Genetic ; Protein Folding ; RNA ; Shock heating ; Specific heat ; Transcription factors ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transcription Factors - physiology ; Transcription, Genetic ; Tunicamycin - pharmacology ; Viruses</subject><ispartof>The Plant cell, 2009-02, Vol.21 (2), p.642-654</ispartof><rights>Copyright 2009 American Society of Plant Biologists</rights><rights>Copyright American Society of Plant Biologists Feb 2009</rights><rights>Copyright © 2009, American Society of Plant Biologists</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-fa5ba5a362fc781dbf4b634e79e64eead6d76cb47bbf5b24fb11ed81a9a3003b3</citedby><cites>FETCH-LOGICAL-c493t-fa5ba5a362fc781dbf4b634e79e64eead6d76cb47bbf5b24fb11ed81a9a3003b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40537417$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40537417$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19244141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sugio, Akiko</creatorcontrib><creatorcontrib>Dreos, René</creatorcontrib><creatorcontrib>Aparicio, Frederic</creatorcontrib><creatorcontrib>Maule, Andrew J</creatorcontrib><title>Cytosolic Protein Response as a Subcomponent of the Wider Heat Shock Response in Arabidopsis</title><title>The Plant cell</title><addtitle>Plant Cell</addtitle><description>In common with a range of environmental and biological stresses, heat shock results in the accumulation of misfolded proteins and a collection of downstream consequences for cellular homeostasis and growth. Within this complex array of responses, the sensing of and responses to misfolded proteins in specific subcellular compartments involves specific chaperones, transcriptional regulators, and expression profiles. Using biological (ectopic protein expression and virus infection) and chemical triggers for misfolded protein accumulation, we have profiled the transcriptional features of the response to misfolded protein accumulation in the cytosol (i.e., the cytoplasmic protein response [CPR]) and identified the effects as a subcomponent of the wider effects induced by heat shock. The CPR in Arabidopsis thaliana is associated with the heat shock promoter element and the involvement of specific heat shock factors (HSFs), notably HSFA2, which appears to be regulated by alternative splicing and non-sense-mediated decay. Characterization of Arabidopsis HSFA2 knockout and overexpression lines showed that HSFA2 is one of the regulatory components of the CPR.</description><subject>Accumulation</subject><subject>Alternative Splicing</subject><subject>Arabidopsis - drug effects</subject><subject>Arabidopsis - metabolism</subject><subject>Arabidopsis - physiology</subject><subject>Arabidopsis Proteins</subject><subject>Azetidinecarboxylic Acid - pharmacology</subject><subject>Biological stress</subject><subject>Cytosol - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Gene Expression Profiling</subject><subject>Gene expression regulation</subject><subject>Genes</subject><subject>Heat shock response</subject><subject>Heat Shock Transcription Factors</subject><subject>Heat-Shock Proteins - genetics</subject><subject>Heat-Shock Proteins - metabolism</subject><subject>Heat-Shock Proteins - physiology</subject><subject>Heat-Shock Response - physiology</subject><subject>Misfolded proteins</subject><subject>Plant cells</subject><subject>Plant Proteins - genetics</subject><subject>Plant Proteins - metabolism</subject><subject>Plant Proteins - physiology</subject><subject>Promoter Regions, Genetic</subject><subject>Protein Folding</subject><subject>RNA</subject><subject>Shock heating</subject><subject>Specific heat</subject><subject>Transcription factors</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription Factors - physiology</subject><subject>Transcription, Genetic</subject><subject>Tunicamycin - pharmacology</subject><subject>Viruses</subject><issn>1040-4651</issn><issn>1532-298X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkUFv1DAQhSMEoqVw5QZYPXDLMmM7TnJBqlaFVqoEYqnggGTZjtP1ko2D7SD13-MqqxY4eeT3vdGzX1G8RFghQvUuTWaF0KxA0KoVj4pjrBgtadt8f5xn4FByUeFR8SzGHQBgje3T4ghbyjlyPC5-rG-Tj35whnwOPlk3ki82Tn6MlqhIFNnM2vh9vrBjIr4naWvJN9fZQC6sSmSz9ebngyXbz4LSrvNTdPF58aRXQ7QvDudJcf3h_Ov6orz69PFyfXZVGt6yVPaq0qpSTNDe1A12uudaMG7r1gpurepEVwujea11X2nKe41ouwZVqxgA0-ykeL_snWa9t53JUYMa5BTcXoVb6ZWT_yqj28ob_1tSIfLH8bzg7WFB8L9mG5Pcu2jsMKjR-jlKUUPLeYsZPP0P3Pk5jPlxkmLTAKMcMrRaIBN8jMH290kQ5F1rMreW50YurWXD67_zP-CHmjLwagF2Mflwr3OoWM2xzvqbRe-Vl-omuCivNxSQAQrkQIH9AQGop9M</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Sugio, Akiko</creator><creator>Dreos, René</creator><creator>Aparicio, Frederic</creator><creator>Maule, Andrew J</creator><general>American Society of Plant Biologists</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7QO</scope><scope>7TM</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090201</creationdate><title>Cytosolic Protein Response as a Subcomponent of the Wider Heat Shock Response in Arabidopsis</title><author>Sugio, Akiko ; Dreos, René ; Aparicio, Frederic ; Maule, Andrew J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-fa5ba5a362fc781dbf4b634e79e64eead6d76cb47bbf5b24fb11ed81a9a3003b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Accumulation</topic><topic>Alternative Splicing</topic><topic>Arabidopsis - drug effects</topic><topic>Arabidopsis - metabolism</topic><topic>Arabidopsis - physiology</topic><topic>Arabidopsis Proteins</topic><topic>Azetidinecarboxylic Acid - pharmacology</topic><topic>Biological stress</topic><topic>Cytosol - metabolism</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Gene Expression Profiling</topic><topic>Gene expression regulation</topic><topic>Genes</topic><topic>Heat shock response</topic><topic>Heat Shock Transcription Factors</topic><topic>Heat-Shock Proteins - genetics</topic><topic>Heat-Shock Proteins - metabolism</topic><topic>Heat-Shock Proteins - physiology</topic><topic>Heat-Shock Response - physiology</topic><topic>Misfolded proteins</topic><topic>Plant cells</topic><topic>Plant Proteins - genetics</topic><topic>Plant Proteins - metabolism</topic><topic>Plant Proteins - physiology</topic><topic>Promoter Regions, Genetic</topic><topic>Protein Folding</topic><topic>RNA</topic><topic>Shock heating</topic><topic>Specific heat</topic><topic>Transcription factors</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription Factors - physiology</topic><topic>Transcription, Genetic</topic><topic>Tunicamycin - pharmacology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sugio, Akiko</creatorcontrib><creatorcontrib>Dreos, René</creatorcontrib><creatorcontrib>Aparicio, Frederic</creatorcontrib><creatorcontrib>Maule, Andrew J</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Plant cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugio, Akiko</au><au>Dreos, René</au><au>Aparicio, Frederic</au><au>Maule, Andrew J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytosolic Protein Response as a Subcomponent of the Wider Heat Shock Response in Arabidopsis</atitle><jtitle>The Plant cell</jtitle><addtitle>Plant Cell</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>21</volume><issue>2</issue><spage>642</spage><epage>654</epage><pages>642-654</pages><issn>1040-4651</issn><eissn>1532-298X</eissn><abstract>In common with a range of environmental and biological stresses, heat shock results in the accumulation of misfolded proteins and a collection of downstream consequences for cellular homeostasis and growth. Within this complex array of responses, the sensing of and responses to misfolded proteins in specific subcellular compartments involves specific chaperones, transcriptional regulators, and expression profiles. Using biological (ectopic protein expression and virus infection) and chemical triggers for misfolded protein accumulation, we have profiled the transcriptional features of the response to misfolded protein accumulation in the cytosol (i.e., the cytoplasmic protein response [CPR]) and identified the effects as a subcomponent of the wider effects induced by heat shock. The CPR in Arabidopsis thaliana is associated with the heat shock promoter element and the involvement of specific heat shock factors (HSFs), notably HSFA2, which appears to be regulated by alternative splicing and non-sense-mediated decay. Characterization of Arabidopsis HSFA2 knockout and overexpression lines showed that HSFA2 is one of the regulatory components of the CPR.</abstract><cop>United States</cop><pub>American Society of Plant Biologists</pub><pmid>19244141</pmid><doi>10.1105/tpc.108.062596</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1040-4651 |
| ispartof | The Plant cell, 2009-02, Vol.21 (2), p.642-654 |
| issn | 1040-4651 1532-298X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2660624 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Accumulation Alternative Splicing Arabidopsis - drug effects Arabidopsis - metabolism Arabidopsis - physiology Arabidopsis Proteins Azetidinecarboxylic Acid - pharmacology Biological stress Cytosol - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Gene Expression Profiling Gene expression regulation Genes Heat shock response Heat Shock Transcription Factors Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Heat-Shock Proteins - physiology Heat-Shock Response - physiology Misfolded proteins Plant cells Plant Proteins - genetics Plant Proteins - metabolism Plant Proteins - physiology Promoter Regions, Genetic Protein Folding RNA Shock heating Specific heat Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Transcription, Genetic Tunicamycin - pharmacology Viruses |
| title | Cytosolic Protein Response as a Subcomponent of the Wider Heat Shock Response in Arabidopsis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T14%3A09%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytosolic%20Protein%20Response%20as%20a%20Subcomponent%20of%20the%20Wider%20Heat%20Shock%20Response%20in%20Arabidopsis&rft.jtitle=The%20Plant%20cell&rft.au=Sugio,%20Akiko&rft.date=2009-02-01&rft.volume=21&rft.issue=2&rft.spage=642&rft.epage=654&rft.pages=642-654&rft.issn=1040-4651&rft.eissn=1532-298X&rft_id=info:doi/10.1105/tpc.108.062596&rft_dat=%3Cjstor_pubme%3E40537417%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=218803240&rft_id=info:pmid/19244141&rft_jstor_id=40537417&rfr_iscdi=true |