The Haptoglobin 2-2 Genotype Is Associated with a Reduced Incidence of Plasmodium falciparum Malaria in Children on the Coast of Kenya

Background. Haptoglobin (Hp) genotype determines the efficiency of hemoglobin clearance after malaria-induced hemolysis and alters antioxidant and immune functions. The Hp2 allele is thought to have spread under strong selection pressure, but it is unclear whether this is due to protection from mala...

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Veröffentlicht in:	Clinical infectious diseases 2007-03, Vol.44 (6), p.802-809
Hauptverfasser:	Atkinson, Sarah H., Mwangi, Tabitha W., Uyoga, Sophie M., Ogada, Edna, Macharia, Alex W., Marsh, Kevin, Prentice, Andrew M., Williams, Thomas N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Distribution Alleles Articles and Commentaries Biological and medical sciences Blood Child Child, Preschool Children Cross-Sectional Studies Developing Countries Female Fever Genetic Predisposition to Disease - epidemiology Genotype Genotype & phenotype Genotypes Glycoproteins Haptoglobins - genetics Hemoglobin Hemoglobins Human protozoal diseases Humans Incidence Infant Infant, Newborn Infections Infectious diseases Kenya - epidemiology Malaria Malaria, Falciparum - epidemiology Malaria, Falciparum - genetics Male Medical sciences Multivariate Analysis Parasites Parasitic diseases Parasitic protozoa Phenotypes Plasmodium falciparum Polymerase Chain Reaction Polymorphism, Genetic Probability Protozoal diseases Regression Analysis Severity of Illness Index Sex Distribution
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