Isoflurane-Sensitive Presynaptic R-Type Calcium Channels Contribute to Inhibitory Synaptic Transmission in the Rat Thalamus

Because inhibitory synaptic transmission is a major mechanism of general anesthesia, we examined the effects of isoflurane on properties of GABAergic inhibitory currents in the reticular thalamic nucleus (nRT) in brain slices. The evoked IPSCs (eIPSCs) and spontaneous miniature synaptic currents (mI...

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Veröffentlicht in:	The Journal of neuroscience 2009-02, Vol.29 (5), p.1434-1445
Hauptverfasser:	Joksovic, Pavle M, Weiergraber, Marco, Lee, WooYong, Struck, Henrik, Schneider, Toni, Todorovic, Slobodan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Channels, R-Type - physiology Cell Line Dose-Response Relationship, Drug Humans In Vitro Techniques Inhibitory Postsynaptic Potentials - drug effects Inhibitory Postsynaptic Potentials - physiology Isoflurane - pharmacology Mice Mice, Inbred C57BL Mice, Knockout Presynaptic Terminals - drug effects Presynaptic Terminals - physiology Rats Rats, Sprague-Dawley Synaptic Transmission - drug effects Synaptic Transmission - physiology Thalamus - drug effects Thalamus - physiology
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