A Protective Role for Type 3 Deiodinase, a Thyroid Hormone-Inactivating Enzyme, in Cochlear Development and Auditory Function

Thyroid hormone is necessary for cochlear development and auditory function, but the factors that control these processes are poorly understood. Previous evidence indicated that in mice, the serum supply of thyroid hormone is augmented within the cochlea itself by type 2 deiodinase, which amplifies...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-04, Vol.150 (4), p.1952-1960
Hauptverfasser:	Ng, Lily, Hernandez, Arturo, He, Wenxuan, Ren, Tianying, Srinivas, Maya, Ma, Michelle, Galton, Valerie A, St. Germain, Donald L, Forrest, Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Auditory system Biological and medical sciences Blotting, Northern Cochlea Cochlea - enzymology Cochlea - growth & development Cochlea - physiology Deactivation Differentiation Enzymes Fundamental and applied biological sciences. Psychology Gene expression Hearing In Situ Hybridization Iodide peroxidase Iodide Peroxidase - genetics Iodide Peroxidase - metabolism Iodide Peroxidase - physiology Mice Mice, Mutant Strains Phenotypes Radioimmunoassay Receptors Sensory stimulation Spiral ganglion Stria vascularis Thyroid Thyroid gland Thyroid Hormone Receptors beta - genetics Thyroid Hormone Receptors beta - physiology Thyroid Hormones - metabolism Triiodothyronine Vertebrates: endocrinology
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