Abdominal aortic aneurysm events in the women’s health initiative: cohort study
Objective To assess the association between potential risk factors and subsequent clinically important abdominal aortic aneurysm events (repairs and ruptures) in women.Design Large prospective observational cohort study with mean follow-up of 7.8 years.Setting 40 clinical centres across the United S...
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Veröffentlicht in: | BMJ 2008-10, Vol.337 (7677), p.1037-1040 |
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description | Objective To assess the association between potential risk factors and subsequent clinically important abdominal aortic aneurysm events (repairs and ruptures) in women.Design Large prospective observational cohort study with mean follow-up of 7.8 years.Setting 40 clinical centres across the United States.Participants 161 808 postmenopausal women aged 50-79 enrolled in the women’s health initiative.Main outcome measures Association of self reported or measured baseline variables with confirmed abdominal aortic aneurysm events assessed with multiple logistic regression.Results Events occurred in 184 women and were strongly associated with age and smoking. Ever smoking, current smoking, and amount smoked all contributed independent risk. Diabetes showed a negative association (odds ratio 0.29, 95% confidence interval 0.13, 0.68), as did postmenopausal hormone therapy. Positive associations were also seen for height, hypertension, cholesterol lowering treatment, and coronary and peripheral artery disease.Conclusions Our findings confirm the strong positive associations of clinically important abdominal aortic aneurysm with age and smoking in women and the negative association with diabetes previously reported in men. |
doi_str_mv | 10.1136/bmj.a1724 |
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Ever smoking, current smoking, and amount smoked all contributed independent risk. Diabetes showed a negative association (odds ratio 0.29, 95% confidence interval 0.13, 0.68), as did postmenopausal hormone therapy. Positive associations were also seen for height, hypertension, cholesterol lowering treatment, and coronary and peripheral artery disease.Conclusions Our findings confirm the strong positive associations of clinically important abdominal aortic aneurysm with age and smoking in women and the negative association with diabetes previously reported in men.</description><edition>International edition</edition><identifier>ISSN: 0959-8138</identifier><identifier>ISSN: 0959-8146</identifier><identifier>ISSN: 0959-535X</identifier><identifier>EISSN: 1468-5833</identifier><identifier>EISSN: 1756-1833</identifier><identifier>DOI: 10.1136/bmj.a1724</identifier><identifier>PMID: 18854591</identifier><identifier>CODEN: BMJOAE</identifier><language>eng</language><publisher>London: British Medical Journal Publishing Group</publisher><subject>Abdomen ; Abdominal aortic aneurysm ; Age patterns ; Aged ; Aneurysm ; Aneurysms ; Aortic aneurysm ; Aortic Aneurysm, Abdominal - epidemiology ; Aortic Aneurysm, Abdominal - surgery ; Aortic aneurysms ; Aortic Rupture - epidemiology ; Aortic Rupture - surgery ; Biological and medical sciences ; Blood pressure ; Body Height ; Cardiovascular disease ; Cerebrovascular disease ; Cholesterol ; Chronic obstructive pulmonary disease ; Cigarette smoking ; Clinical trials ; Cohort Studies ; Coronary vessels ; Diabetes ; Diabetes mellitus ; Female ; Gender differences ; General aspects ; Hormone Replacement Therapy - statistics & numerical data ; Hormone therapy ; Humans ; Hyperlipidemia ; Hypertension ; Medical sciences ; Men ; Middle Aged ; Miscellaneous ; Observational studies ; Older women ; Peripheral artery disease ; Prevalence ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Regression (Psychology) ; Risk factors ; Skin cancer ; Smoking ; Smoking - epidemiology ; Thromboembolism ; United States - epidemiology ; Vein & artery diseases ; Women's Health ; Womens health</subject><ispartof>BMJ, 2008-10, Vol.337 (7677), p.1037-1040</ispartof><rights>Lederle et al 2008</rights><rights>Copyright 2008 BMJ Publishing Group Ltd.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Oct 14, 2008</rights><rights>Copyright BMJ Publishing Group Nov 1, 2008</rights><rights>Lederle et al 2008 2008 Lederle et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b714t-d8ead73e9f2951a07d3423ff23f943a923c97ab08a3df44c0325db07db6fd6873</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bmj.com/content/337/bmj.a1724.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttp://bmj.com/content/337/bmj.a1724.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>114,115,230,314,776,780,799,881,3183,23550,27901,27902,30976,30977,57992,58225,77342,77373</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20792422$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18854591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lederle, Frank A</creatorcontrib><creatorcontrib>Larson, Joseph C</creatorcontrib><creatorcontrib>Margolis, Karen L</creatorcontrib><creatorcontrib>Allison, Matthew A</creatorcontrib><creatorcontrib>Freiberg, Matthew S</creatorcontrib><creatorcontrib>Cochrane, Barbara B</creatorcontrib><creatorcontrib>Graettinger, William F</creatorcontrib><creatorcontrib>Curb, J David</creatorcontrib><creatorcontrib>Women's Health Initiative Cohort Study</creatorcontrib><title>Abdominal aortic aneurysm events in the women’s health initiative: cohort study</title><title>BMJ</title><addtitle>BMJ</addtitle><description>Objective To assess the association between potential risk factors and subsequent clinically important abdominal aortic aneurysm events (repairs and ruptures) in women.Design Large prospective observational cohort study with mean follow-up of 7.8 years.Setting 40 clinical centres across the United States.Participants 161 808 postmenopausal women aged 50-79 enrolled in the women’s health initiative.Main outcome measures Association of self reported or measured baseline variables with confirmed abdominal aortic aneurysm events assessed with multiple logistic regression.Results Events occurred in 184 women and were strongly associated with age and smoking. Ever smoking, current smoking, and amount smoked all contributed independent risk. Diabetes showed a negative association (odds ratio 0.29, 95% confidence interval 0.13, 0.68), as did postmenopausal hormone therapy. Positive associations were also seen for height, hypertension, cholesterol lowering treatment, and coronary and peripheral artery disease.Conclusions Our findings confirm the strong positive associations of clinically important abdominal aortic aneurysm with age and smoking in women and the negative association with diabetes previously reported in men.</description><subject>Abdomen</subject><subject>Abdominal aortic aneurysm</subject><subject>Age patterns</subject><subject>Aged</subject><subject>Aneurysm</subject><subject>Aneurysms</subject><subject>Aortic aneurysm</subject><subject>Aortic Aneurysm, Abdominal - epidemiology</subject><subject>Aortic Aneurysm, Abdominal - surgery</subject><subject>Aortic aneurysms</subject><subject>Aortic Rupture - epidemiology</subject><subject>Aortic Rupture - surgery</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Body Height</subject><subject>Cardiovascular disease</subject><subject>Cerebrovascular disease</subject><subject>Cholesterol</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cigarette smoking</subject><subject>Clinical trials</subject><subject>Cohort Studies</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Female</subject><subject>Gender differences</subject><subject>General aspects</subject><subject>Hormone Replacement Therapy - statistics & numerical data</subject><subject>Hormone therapy</subject><subject>Humans</subject><subject>Hyperlipidemia</subject><subject>Hypertension</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Observational studies</subject><subject>Older women</subject><subject>Peripheral artery disease</subject><subject>Prevalence</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Regression (Psychology)</subject><subject>Risk factors</subject><subject>Skin cancer</subject><subject>Smoking</subject><subject>Smoking - epidemiology</subject><subject>Thromboembolism</subject><subject>United States - epidemiology</subject><subject>Vein & artery diseases</subject><subject>Women's Health</subject><subject>Womens health</subject><issn>0959-8138</issn><issn>0959-8146</issn><issn>0959-535X</issn><issn>1468-5833</issn><issn>1756-1833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>7QJ</sourceid><recordid>eNqF0ctu1DAUBmALgeiodMEDgCJuEosU3y8skKoRN7XiptIFG8tJHMbTJC62MzA7XoPX40nwkNFQkCoWkaWcz0fH5wfgNoKHCBH-pOqXhwYJTK-BGaJclkwSch3MoGKqlIjIPXAQ4xJCiImQirObYA9JyShTaAbeH1WN791gusL4kFxdmMGOYR37wq7skGLhhiItbPHV93b4-f1HLBbWdGmR_7vkTHIr-7So_SJfLmIam_UtcKM1XbQH23MffHzx_HT-qjx5-_L1_OikrASiqWykNY0gVrVYMWSgaAjFpG3zpygxCpNaCVNBaUjTUlpDgllTZVbxtuFSkH3wbOp7MVa9beo8bDCdvgiuN2GtvXH678rgFvqzX2nMmZSY5QaPtg2C_zLamHTvYm27Lm_Aj1HzvCtJBfkvZAILKijN8N4_cOnHkHcbNYY0B4AIyuj-VQgJISHnGMGsHk-qDj7GYNvdwxDUm9x1zl3_zj3bu5c38UduU87g4RaYWJuuDWaoXdw5DIXCFOPs7kxuGZMPl-oMIaQ2Ky-nuovJftvVTTjXXBDB9JuzuT7jx_TT8YdT_S77B5PfzHr1_L8A9uXa8A</recordid><startdate>20081014</startdate><enddate>20081014</enddate><creator>Lederle, Frank A</creator><creator>Larson, Joseph C</creator><creator>Margolis, Karen L</creator><creator>Allison, Matthew A</creator><creator>Freiberg, Matthew S</creator><creator>Cochrane, Barbara B</creator><creator>Graettinger, William F</creator><creator>Curb, J David</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group Ltd</general><scope>9YT</scope><scope>ACMMV</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QJ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20081014</creationdate><title>Abdominal aortic aneurysm events in the women’s health initiative: cohort study</title><author>Lederle, Frank A ; Larson, Joseph C ; Margolis, Karen L ; Allison, Matthew A ; Freiberg, Matthew S ; Cochrane, Barbara B ; Graettinger, William F ; Curb, J David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b714t-d8ead73e9f2951a07d3423ff23f943a923c97ab08a3df44c0325db07db6fd6873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Abdomen</topic><topic>Abdominal aortic aneurysm</topic><topic>Age patterns</topic><topic>Aged</topic><topic>Aneurysm</topic><topic>Aneurysms</topic><topic>Aortic aneurysm</topic><topic>Aortic Aneurysm, Abdominal - epidemiology</topic><topic>Aortic Aneurysm, Abdominal - surgery</topic><topic>Aortic aneurysms</topic><topic>Aortic Rupture - epidemiology</topic><topic>Aortic Rupture - surgery</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Body Height</topic><topic>Cardiovascular disease</topic><topic>Cerebrovascular disease</topic><topic>Cholesterol</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cigarette smoking</topic><topic>Clinical trials</topic><topic>Cohort Studies</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Female</topic><topic>Gender differences</topic><topic>General aspects</topic><topic>Hormone Replacement Therapy - statistics & numerical data</topic><topic>Hormone therapy</topic><topic>Humans</topic><topic>Hyperlipidemia</topic><topic>Hypertension</topic><topic>Medical sciences</topic><topic>Men</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Observational studies</topic><topic>Older women</topic><topic>Peripheral artery disease</topic><topic>Prevalence</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Regression (Psychology)</topic><topic>Risk factors</topic><topic>Skin cancer</topic><topic>Smoking</topic><topic>Smoking - epidemiology</topic><topic>Thromboembolism</topic><topic>United States - epidemiology</topic><topic>Vein & artery diseases</topic><topic>Women's Health</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lederle, Frank A</creatorcontrib><creatorcontrib>Larson, Joseph C</creatorcontrib><creatorcontrib>Margolis, Karen L</creatorcontrib><creatorcontrib>Allison, Matthew A</creatorcontrib><creatorcontrib>Freiberg, Matthew S</creatorcontrib><creatorcontrib>Cochrane, Barbara B</creatorcontrib><creatorcontrib>Graettinger, William F</creatorcontrib><creatorcontrib>Curb, J David</creatorcontrib><creatorcontrib>Women's Health Initiative Cohort Study</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lederle, Frank A</au><au>Larson, Joseph C</au><au>Margolis, Karen L</au><au>Allison, Matthew A</au><au>Freiberg, Matthew S</au><au>Cochrane, Barbara B</au><au>Graettinger, William F</au><au>Curb, J David</au><aucorp>Women's Health Initiative Cohort Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abdominal aortic aneurysm events in the women’s health initiative: cohort study</atitle><jtitle>BMJ</jtitle><addtitle>BMJ</addtitle><date>2008-10-14</date><risdate>2008</risdate><volume>337</volume><issue>7677</issue><spage>1037</spage><epage>1040</epage><pages>1037-1040</pages><issn>0959-8138</issn><issn>0959-8146</issn><issn>0959-535X</issn><eissn>1468-5833</eissn><eissn>1756-1833</eissn><coden>BMJOAE</coden><abstract>Objective To assess the association between potential risk factors and subsequent clinically important abdominal aortic aneurysm events (repairs and ruptures) in women.Design Large prospective observational cohort study with mean follow-up of 7.8 years.Setting 40 clinical centres across the United States.Participants 161 808 postmenopausal women aged 50-79 enrolled in the women’s health initiative.Main outcome measures Association of self reported or measured baseline variables with confirmed abdominal aortic aneurysm events assessed with multiple logistic regression.Results Events occurred in 184 women and were strongly associated with age and smoking. Ever smoking, current smoking, and amount smoked all contributed independent risk. Diabetes showed a negative association (odds ratio 0.29, 95% confidence interval 0.13, 0.68), as did postmenopausal hormone therapy. Positive associations were also seen for height, hypertension, cholesterol lowering treatment, and coronary and peripheral artery disease.Conclusions Our findings confirm the strong positive associations of clinically important abdominal aortic aneurysm with age and smoking in women and the negative association with diabetes previously reported in men.</abstract><cop>London</cop><pub>British Medical Journal Publishing Group</pub><pmid>18854591</pmid><doi>10.1136/bmj.a1724</doi><tpages>4</tpages><edition>International edition</edition><oa>free_for_read</oa></addata></record> |
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subjects | Abdomen Abdominal aortic aneurysm Age patterns Aged Aneurysm Aneurysms Aortic aneurysm Aortic Aneurysm, Abdominal - epidemiology Aortic Aneurysm, Abdominal - surgery Aortic aneurysms Aortic Rupture - epidemiology Aortic Rupture - surgery Biological and medical sciences Blood pressure Body Height Cardiovascular disease Cerebrovascular disease Cholesterol Chronic obstructive pulmonary disease Cigarette smoking Clinical trials Cohort Studies Coronary vessels Diabetes Diabetes mellitus Female Gender differences General aspects Hormone Replacement Therapy - statistics & numerical data Hormone therapy Humans Hyperlipidemia Hypertension Medical sciences Men Middle Aged Miscellaneous Observational studies Older women Peripheral artery disease Prevalence Public health. Hygiene Public health. Hygiene-occupational medicine Regression (Psychology) Risk factors Skin cancer Smoking Smoking - epidemiology Thromboembolism United States - epidemiology Vein & artery diseases Women's Health Womens health |
title | Abdominal aortic aneurysm events in the women’s health initiative: cohort study |
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