Abdominal aortic aneurysm events in the women’s health initiative: cohort study

Objective To assess the association between potential risk factors and subsequent clinically important abdominal aortic aneurysm events (repairs and ruptures) in women.Design Large prospective observational cohort study with mean follow-up of 7.8 years.Setting 40 clinical centres across the United S...

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Veröffentlicht in:BMJ 2008-10, Vol.337 (7677), p.1037-1040
Hauptverfasser: Lederle, Frank A, Larson, Joseph C, Margolis, Karen L, Allison, Matthew A, Freiberg, Matthew S, Cochrane, Barbara B, Graettinger, William F, Curb, J David
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container_end_page 1040
container_issue 7677
container_start_page 1037
container_title BMJ
container_volume 337
creator Lederle, Frank A
Larson, Joseph C
Margolis, Karen L
Allison, Matthew A
Freiberg, Matthew S
Cochrane, Barbara B
Graettinger, William F
Curb, J David
description Objective To assess the association between potential risk factors and subsequent clinically important abdominal aortic aneurysm events (repairs and ruptures) in women.Design Large prospective observational cohort study with mean follow-up of 7.8 years.Setting 40 clinical centres across the United States.Participants 161 808 postmenopausal women aged 50-79 enrolled in the women’s health initiative.Main outcome measures Association of self reported or measured baseline variables with confirmed abdominal aortic aneurysm events assessed with multiple logistic regression.Results Events occurred in 184 women and were strongly associated with age and smoking. Ever smoking, current smoking, and amount smoked all contributed independent risk. Diabetes showed a negative association (odds ratio 0.29, 95% confidence interval 0.13, 0.68), as did postmenopausal hormone therapy. Positive associations were also seen for height, hypertension, cholesterol lowering treatment, and coronary and peripheral artery disease.Conclusions Our findings confirm the strong positive associations of clinically important abdominal aortic aneurysm with age and smoking in women and the negative association with diabetes previously reported in men.
doi_str_mv 10.1136/bmj.a1724
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Ever smoking, current smoking, and amount smoked all contributed independent risk. Diabetes showed a negative association (odds ratio 0.29, 95% confidence interval 0.13, 0.68), as did postmenopausal hormone therapy. Positive associations were also seen for height, hypertension, cholesterol lowering treatment, and coronary and peripheral artery disease.Conclusions Our findings confirm the strong positive associations of clinically important abdominal aortic aneurysm with age and smoking in women and the negative association with diabetes previously reported in men.</description><edition>International edition</edition><identifier>ISSN: 0959-8138</identifier><identifier>ISSN: 0959-8146</identifier><identifier>ISSN: 0959-535X</identifier><identifier>EISSN: 1468-5833</identifier><identifier>EISSN: 1756-1833</identifier><identifier>DOI: 10.1136/bmj.a1724</identifier><identifier>PMID: 18854591</identifier><identifier>CODEN: BMJOAE</identifier><language>eng</language><publisher>London: British Medical Journal Publishing Group</publisher><subject>Abdomen ; Abdominal aortic aneurysm ; Age patterns ; Aged ; Aneurysm ; Aneurysms ; Aortic aneurysm ; Aortic Aneurysm, Abdominal - epidemiology ; Aortic Aneurysm, Abdominal - surgery ; Aortic aneurysms ; Aortic Rupture - epidemiology ; Aortic Rupture - surgery ; Biological and medical sciences ; Blood pressure ; Body Height ; Cardiovascular disease ; Cerebrovascular disease ; Cholesterol ; Chronic obstructive pulmonary disease ; Cigarette smoking ; Clinical trials ; Cohort Studies ; Coronary vessels ; Diabetes ; Diabetes mellitus ; Female ; Gender differences ; General aspects ; Hormone Replacement Therapy - statistics &amp; numerical data ; Hormone therapy ; Humans ; Hyperlipidemia ; Hypertension ; Medical sciences ; Men ; Middle Aged ; Miscellaneous ; Observational studies ; Older women ; Peripheral artery disease ; Prevalence ; Public health. Hygiene ; Public health. 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Ever smoking, current smoking, and amount smoked all contributed independent risk. Diabetes showed a negative association (odds ratio 0.29, 95% confidence interval 0.13, 0.68), as did postmenopausal hormone therapy. Positive associations were also seen for height, hypertension, cholesterol lowering treatment, and coronary and peripheral artery disease.Conclusions Our findings confirm the strong positive associations of clinically important abdominal aortic aneurysm with age and smoking in women and the negative association with diabetes previously reported in men.</description><subject>Abdomen</subject><subject>Abdominal aortic aneurysm</subject><subject>Age patterns</subject><subject>Aged</subject><subject>Aneurysm</subject><subject>Aneurysms</subject><subject>Aortic aneurysm</subject><subject>Aortic Aneurysm, Abdominal - epidemiology</subject><subject>Aortic Aneurysm, Abdominal - surgery</subject><subject>Aortic aneurysms</subject><subject>Aortic Rupture - epidemiology</subject><subject>Aortic Rupture - surgery</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Body Height</subject><subject>Cardiovascular disease</subject><subject>Cerebrovascular disease</subject><subject>Cholesterol</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cigarette smoking</subject><subject>Clinical trials</subject><subject>Cohort Studies</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Female</subject><subject>Gender differences</subject><subject>General aspects</subject><subject>Hormone Replacement Therapy - statistics &amp; numerical data</subject><subject>Hormone therapy</subject><subject>Humans</subject><subject>Hyperlipidemia</subject><subject>Hypertension</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Observational studies</subject><subject>Older women</subject><subject>Peripheral artery disease</subject><subject>Prevalence</subject><subject>Public health. 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Larson, Joseph C ; Margolis, Karen L ; Allison, Matthew A ; Freiberg, Matthew S ; Cochrane, Barbara B ; Graettinger, William F ; Curb, J David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b714t-d8ead73e9f2951a07d3423ff23f943a923c97ab08a3df44c0325db07db6fd6873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Abdomen</topic><topic>Abdominal aortic aneurysm</topic><topic>Age patterns</topic><topic>Aged</topic><topic>Aneurysm</topic><topic>Aneurysms</topic><topic>Aortic aneurysm</topic><topic>Aortic Aneurysm, Abdominal - epidemiology</topic><topic>Aortic Aneurysm, Abdominal - surgery</topic><topic>Aortic aneurysms</topic><topic>Aortic Rupture - epidemiology</topic><topic>Aortic Rupture - surgery</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Body Height</topic><topic>Cardiovascular disease</topic><topic>Cerebrovascular disease</topic><topic>Cholesterol</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cigarette smoking</topic><topic>Clinical trials</topic><topic>Cohort Studies</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Female</topic><topic>Gender differences</topic><topic>General aspects</topic><topic>Hormone Replacement Therapy - statistics &amp; 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Ever smoking, current smoking, and amount smoked all contributed independent risk. Diabetes showed a negative association (odds ratio 0.29, 95% confidence interval 0.13, 0.68), as did postmenopausal hormone therapy. Positive associations were also seen for height, hypertension, cholesterol lowering treatment, and coronary and peripheral artery disease.Conclusions Our findings confirm the strong positive associations of clinically important abdominal aortic aneurysm with age and smoking in women and the negative association with diabetes previously reported in men.</abstract><cop>London</cop><pub>British Medical Journal Publishing Group</pub><pmid>18854591</pmid><doi>10.1136/bmj.a1724</doi><tpages>4</tpages><edition>International edition</edition><oa>free_for_read</oa></addata></record>
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source Applied Social Sciences Index & Abstracts (ASSIA); Jstor Complete Legacy; MEDLINE; BMJ Journals - NESLi2; Alma/SFX Local Collection
subjects Abdomen
Abdominal aortic aneurysm
Age patterns
Aged
Aneurysm
Aneurysms
Aortic aneurysm
Aortic Aneurysm, Abdominal - epidemiology
Aortic Aneurysm, Abdominal - surgery
Aortic aneurysms
Aortic Rupture - epidemiology
Aortic Rupture - surgery
Biological and medical sciences
Blood pressure
Body Height
Cardiovascular disease
Cerebrovascular disease
Cholesterol
Chronic obstructive pulmonary disease
Cigarette smoking
Clinical trials
Cohort Studies
Coronary vessels
Diabetes
Diabetes mellitus
Female
Gender differences
General aspects
Hormone Replacement Therapy - statistics & numerical data
Hormone therapy
Humans
Hyperlipidemia
Hypertension
Medical sciences
Men
Middle Aged
Miscellaneous
Observational studies
Older women
Peripheral artery disease
Prevalence
Public health. Hygiene
Public health. Hygiene-occupational medicine
Regression (Psychology)
Risk factors
Skin cancer
Smoking
Smoking - epidemiology
Thromboembolism
United States - epidemiology
Vein & artery diseases
Women's Health
Womens health
title Abdominal aortic aneurysm events in the women’s health initiative: cohort study
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