The M-type receptor PLA2R regulates senescence through the p53 pathway

Senescence is a stable proliferative arrest induced by various stresses such as telomere erosion, oncogenic or oxidative stress. Compelling evidence suggests that it acts as a barrier against tumour development. Describing new mechanisms that favour an escape from senescence can thus reveal new insi...

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Veröffentlicht in:	EMBO reports 2009-03, Vol.10 (3), p.271-277
Hauptverfasser:	Augert, Arnaud, Payré, Christine, de Launoit, Yvan, Gil, Jesus, Lambeau, Gérard, Bernard, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Autoantibodies Blotting, Western Cancer Cell Aging Cell Line Cellular Senescence - physiology Chi-Square Distribution Deoxyribonucleic acid DNA DNA damage Down-Regulation EMBO06 EMBO24 Epitopes Fibroblasts Fibroblasts - cytology Fibroblasts - physiology Gene Knockdown Techniques Genetics Glomerulonephritis, Membranous Humans Immunoglobulin G Kidney Glomerulus Life Sciences Mass Spectrometry Molecular biology Oncology Oxidative stress p53 PLA2R Reactive Oxygen Species Reactive Oxygen Species - metabolism Receptors, Phospholipase A2 Receptors, Phospholipase A2 - genetics Receptors, Phospholipase A2 - metabolism Scientific Report senescence Signal Transduction Signal Transduction - physiology Tumor Suppressor Protein p53 Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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