Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons

Abstract Mechanisms underlying hypoxia-induced neuronal adaptation have not been fully elucidated. In the present study we investigated glucose metabolism and the activities of glycolytic and TCA cycle enzymes in cerebro-cortical neurons exposed to hypoxia (3 days in 1% of O2 ) or normoxia (room air...

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Veröffentlicht in:	Brain research 2008-09, Vol.1229, p.147-154
Hauptverfasser:	Malthankar-Phatak, Gauri H, Patel, Anant B, Xia, Ying, Hong, Soonsun, Chowdhury, Golam M.I, Behar, Kevin L, Orina, Isaac A, Lai, James C.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry and metabolism Biological and medical sciences Carbon Isotopes - metabolism Cells, Cultured Central nervous system Cerebellum - cytology Cerebral Cortex - cytology Citrate (si)-Synthase - metabolism Continuous hypoxia Embryo, Mammalian Energy Metabolism - physiology Female Fundamental and applied biological sciences. Psychology Glucose - metabolism Glutamate Dehydrogenase - metabolism Glycolysis Hexokinase - metabolism Hypoxia - physiopathology L-Lactate Dehydrogenase - metabolism Lactic Acid - metabolism Magnetic Resonance Spectroscopy - methods Metabolic flux Neurology Neurons - physiology NMR Pregnancy Pyruvate Kinase - metabolism Rats Rats, Sprague-Dawley TCA cycle Time Factors Vertebrates: nervous system and sense organs
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