Involvement of MicroRNAs in Hydrogen Peroxide-mediated Gene Regulation and Cellular Injury Response in Vascular Smooth Muscle Cells

MicroRNAs (miRNAs) comprise a novel class of endogenous, small, noncoding RNAs that negatively regulate ∼30% of genes in a cell via degradation or translational inhibition of their target mRNAs. However, the effects of reactive oxygen species (ROS) on miRNA expression and the roles of miRNAs in ROS-...

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Veröffentlicht in:	The Journal of biological chemistry 2009-03, Vol.284 (12), p.7903-7913
Hauptverfasser:	Lin, Ying, Liu, Xiaojun, Cheng, Yunhui, Yang, Jian, Huo, Yuqing, Zhang, Chunxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Gene Expression Profiling Gene Expression Regulation - drug effects Hydrogen Peroxide - pharmacology Male MicroRNAs - metabolism Muscle, Smooth, Vascular - injuries Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Oligonucleotide Array Sequence Analysis Oxidants - pharmacology Rats Rats, Sprague-Dawley RNA Precursors - metabolism RNA-Mediated Regulation and Noncoding Rnas Transcription Factor AP-1 - metabolism Vascular Diseases - metabolism Vascular Diseases - pathology
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