Regulation of B cell tolerance by 129‐derived chromosome 1 loci in C57BL/6 mice

Objective Systemic lupus erythematosus is a multifactorial disease with a strong genetic component. Previous studies have shown that a 129‐derived chromosome 1 interval (Sle16) on the C57BL/6 (B6) background is sufficient to induce humoral autoimmunity. The aim of the present study was to elucidate...

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Veröffentlicht in:	Arthritis and rheumatism 2008-07, Vol.58 (7), p.2131-2141
Hauptverfasser:	Fossati‐Jimack, Liliane, Cortes‐Hernandez, Josefina, Norsworthy, Peter J., Cook, H. Terence, Walport, Mark J., Botto, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies Autoimmunity - immunology B-Lymphocytes - immunology Biological and medical sciences Chromosomes, Human, Pair 1 - immunology Diseases of the osteoarticular system DNA, Single-Stranded Humans Immunoglobulin Class Switching - immunology Immunoglobulin G Immunoglobulin M Lupus Erythematosus, Systemic - immunology Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Phenotype Systemic Lupus Erythematosus Basic Science Studies
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