Repression of Sestrin Family Genes Contributes to Oncogenic Ras-Induced ROS Up-Regulation and Genetic Instability

Oncogenic mutations within RAS genes and inactivation of p53 are the most common events in cancer. Earlier we reported that activated Ras contributes to chromosome instability, especially in p53-deficient cells. Here we show that an increase in intracellular reactive oxygen species (ROS) and oxidati...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-05, Vol.67 (10), p.4671-4678
Hauptverfasser:	Kopnin, Pavel B., Agapova, Larissa S., Kopnin, Boris P., Chumakov, Peter M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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