Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity

The clinical phenotype of Huntington's disease (HD) is far more complex and variable than depictions of it as a progressive movement disorder dominated by neostriatal pathology represent. The availability of novel neuro-imaging methods has enabled us to evaluate cerebral cortical changes in HD,...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2008-04, Vol.131 (4), p.1057-1068
Hauptverfasser:	Rosas, H. Diana, Salat, David H., Lee, Stephanie Y., Zaleta, Alexandra K., Pappu, Vasanth, Fischl, Bruce, Greve, Doug, Hevelone, Nathanael, Hersch, Steven M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Atrophy Biological and medical sciences biomarker Brain Mapping - methods Cerebral Cortex - pathology Cerebral Cortex - physiopathology Cognition Disorders - etiology Cognition Disorders - pathology cortex Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Female Humans Huntington Disease - pathology Huntington Disease - physiopathology Huntington Disease - psychology Huntington's disease Image Interpretation, Computer-Assisted - methods Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Models, Neurological Neurology Neuropsychological Tests Phenotype phenotypic variability
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