Detergent-Insoluble EAAC1/EAAT3 Aberrantly Accumulates in Hippocampal Neurons of Alzheimer's Disease Patients

Disturbed glutamate homeostasis may contribute to the pathological processes involved in Alzheimer's disease (AD). Once glutamate is released from synapses or from other intracellular sources, it is rapidly cleared by glutamate transporters. EAAC1 (also called EAAT3 or SLC1A1) is the primary gl...

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Veröffentlicht in:	Brain pathology (Zurich, Switzerland) Switzerland), 2009-04, Vol.19 (2), p.267-278
Hauptverfasser:	Duerson, Kevin, Woltjer, Randall L., Mookherjee, Paramita, Leverenz, James B., Montine, Thomas J., Bird, Thomas D., Pow, David V., Rauen, Thomas, Cook, David G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Blotting, Western Detergents - pharmacology Excitatory Amino Acid Transporter 3 - chemistry Excitatory Amino Acid Transporter 3 - metabolism excitotoxicity Female Frontal Lobe - metabolism Frontal Lobe - pathology Glutamate toxicity Glutamate Uptake Hippocampus - metabolism Hippocampus - pathology Humans Immunohistochemistry Male memantine neurodegeneration Neurofibrillary Tangles - metabolism Neurons - metabolism Octoxynol - pharmacology Parkinson Disease - metabolism Parkinson Disease - pathology Plaque, Amyloid - metabolism protein aggregation Solubility Synaptic dysfunction
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