Persistent organic pollutants and anti-thyroid peroxidase levels in Akwesasne Mohawk young adults
Persistent organic pollutants, such as polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), and p, p′ -dichlorophenyldichloroethylene (DDE), have been found to elicit a broad spectrum of biologic, metabolic, and immunologic responses. The potential of these pollutants to impair immune response...
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creator | Schell, Lawrence M. Gallo, Mia V. Ravenscroft, Julia DeCaprio, Anthony P. |
description | Persistent organic pollutants, such as polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), and
p,
p′
-dichlorophenyldichloroethylene (DDE), have been found to elicit a broad spectrum of biologic, metabolic, and immunologic responses. The potential of these pollutants to impair immune responses and trigger autoimmune disease is of growing concern, given their structural similarity to thyroid hormones and their potential to modulate the mechanisms and interfere with the binding of these hormones. We examine the relationship of different groupings of PCBs, according to chlorination and structure, and of
p,
p′-DDE and HCB to anti-thyroid peroxidase antibody, a useful tool in the evaluation of thyroid dysfunction, among 115 young adults of the Akwesasne Mohawk Nation.
Overall, 18 participants (15.4%) had anti-thyroid peroxidase antibodies (TPOAb) levels above the normal laboratory reference range (23% of females, 9% of males). Among participants who were breast fed (
n=47), those with an elevated TPOAb level had significantly higher levels of all PCB groupings, with the exception of levels of non-persistent PCBs which did not differ significantly. Levels of
p,
p′-DDE were also significantly elevated, while HCB and mirex were not higher among those with elevated TPOAb. Also, after stratifying by breast-feeding status, participants who were breast fed showed significant, positive relationships between TPOAb levels and all PCB groupings, except groups comprised of non-persistent PCBs, and with
p,
p′-DDE, HCB, and mirex. No effects were evident among non-breast-fed young adults.
Further studies are necessary to elucidate the site and mechanism of action of these persistent organic pollutants (POPs) and to establish thresholds for these effects, especially among populations with background levels of toxicant exposure. |
doi_str_mv | 10.1016/j.envres.2008.08.015 |
format | Article |
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p,
p′
-dichlorophenyldichloroethylene (DDE), have been found to elicit a broad spectrum of biologic, metabolic, and immunologic responses. The potential of these pollutants to impair immune responses and trigger autoimmune disease is of growing concern, given their structural similarity to thyroid hormones and their potential to modulate the mechanisms and interfere with the binding of these hormones. We examine the relationship of different groupings of PCBs, according to chlorination and structure, and of
p,
p′-DDE and HCB to anti-thyroid peroxidase antibody, a useful tool in the evaluation of thyroid dysfunction, among 115 young adults of the Akwesasne Mohawk Nation.
Overall, 18 participants (15.4%) had anti-thyroid peroxidase antibodies (TPOAb) levels above the normal laboratory reference range (23% of females, 9% of males). Among participants who were breast fed (
n=47), those with an elevated TPOAb level had significantly higher levels of all PCB groupings, with the exception of levels of non-persistent PCBs which did not differ significantly. Levels of
p,
p′-DDE were also significantly elevated, while HCB and mirex were not higher among those with elevated TPOAb. Also, after stratifying by breast-feeding status, participants who were breast fed showed significant, positive relationships between TPOAb levels and all PCB groupings, except groups comprised of non-persistent PCBs, and with
p,
p′-DDE, HCB, and mirex. No effects were evident among non-breast-fed young adults.
Further studies are necessary to elucidate the site and mechanism of action of these persistent organic pollutants (POPs) and to establish thresholds for these effects, especially among populations with background levels of toxicant exposure.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/j.envres.2008.08.015</identifier><identifier>PMID: 18995849</identifier><identifier>CODEN: ENVRAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adolescent ; Anti-thyroid peroxidase ; Autoantibodies - blood ; Biological and medical sciences ; Environmental Exposure - adverse effects ; Environmental Exposure - analysis ; Environmental Pollutants - blood ; Environmental Pollutants - toxicity ; Environmental pollutants toxicology ; Female ; General aspects ; Humans ; Hydrocarbons, Chlorinated - blood ; Hydrocarbons, Chlorinated - toxicity ; Indians, North American ; Iodide Peroxidase - immunology ; Male ; Medical sciences ; Native American ; New York ; PCBs ; Thyroid Hormones - blood ; Toxicology ; Young Adult</subject><ispartof>Environmental research, 2009-01, Vol.109 (1), p.86-92</ispartof><rights>2008 Elsevier Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588t-9d0f15c2656e6dd62bddba1a372a95d1a2ed0ca43343585868b1c29768d15ee63</citedby><cites>FETCH-LOGICAL-c588t-9d0f15c2656e6dd62bddba1a372a95d1a2ed0ca43343585868b1c29768d15ee63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.envres.2008.08.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21022527$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18995849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schell, Lawrence M.</creatorcontrib><creatorcontrib>Gallo, Mia V.</creatorcontrib><creatorcontrib>Ravenscroft, Julia</creatorcontrib><creatorcontrib>DeCaprio, Anthony P.</creatorcontrib><title>Persistent organic pollutants and anti-thyroid peroxidase levels in Akwesasne Mohawk young adults</title><title>Environmental research</title><addtitle>Environ Res</addtitle><description>Persistent organic pollutants, such as polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), and
p,
p′
-dichlorophenyldichloroethylene (DDE), have been found to elicit a broad spectrum of biologic, metabolic, and immunologic responses. The potential of these pollutants to impair immune responses and trigger autoimmune disease is of growing concern, given their structural similarity to thyroid hormones and their potential to modulate the mechanisms and interfere with the binding of these hormones. We examine the relationship of different groupings of PCBs, according to chlorination and structure, and of
p,
p′-DDE and HCB to anti-thyroid peroxidase antibody, a useful tool in the evaluation of thyroid dysfunction, among 115 young adults of the Akwesasne Mohawk Nation.
Overall, 18 participants (15.4%) had anti-thyroid peroxidase antibodies (TPOAb) levels above the normal laboratory reference range (23% of females, 9% of males). Among participants who were breast fed (
n=47), those with an elevated TPOAb level had significantly higher levels of all PCB groupings, with the exception of levels of non-persistent PCBs which did not differ significantly. Levels of
p,
p′-DDE were also significantly elevated, while HCB and mirex were not higher among those with elevated TPOAb. Also, after stratifying by breast-feeding status, participants who were breast fed showed significant, positive relationships between TPOAb levels and all PCB groupings, except groups comprised of non-persistent PCBs, and with
p,
p′-DDE, HCB, and mirex. No effects were evident among non-breast-fed young adults.
Further studies are necessary to elucidate the site and mechanism of action of these persistent organic pollutants (POPs) and to establish thresholds for these effects, especially among populations with background levels of toxicant exposure.</description><subject>Adolescent</subject><subject>Anti-thyroid peroxidase</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental Exposure - analysis</subject><subject>Environmental Pollutants - blood</subject><subject>Environmental Pollutants - toxicity</subject><subject>Environmental pollutants toxicology</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Hydrocarbons, Chlorinated - blood</subject><subject>Hydrocarbons, Chlorinated - toxicity</subject><subject>Indians, North American</subject><subject>Iodide Peroxidase - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Native American</subject><subject>New York</subject><subject>PCBs</subject><subject>Thyroid Hormones - blood</subject><subject>Toxicology</subject><subject>Young Adult</subject><issn>0013-9351</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1vEzEQhi0EoiHwDxDyBW4bbO_a8V6QqqoFpCI4wNma2JPEqWMH25uSf9-NErVwQRrLGvnxOx8vIW85m3HG1cfNDOM-Y5kJxvTsGFw-IxPOetWwXrbPyYQx3jZ9K_kFeVXKZky5bNlLcsF130vd9RMCPzAXXyrGSlNeQfSW7lIIQ4VYC4XoxlN9U9eHnLyjO8zpj3dQkAbcYyjUR3p5d48FSkT6La3h_o4e0hBXFNwQanlNXiwhFHxzvqfk1831z6svze33z1-vLm8bK7WuTe_YkksrlFSonFNi4dwCOLRzAb10HAQ6ZqFr266VWmqlF9yKfq604xJRtVPy6aS7GxZbdHacKEMwu-y3kA8mgTf_vkS_Nqu0N8eSqtOjwIezQE6_ByzVbH2xGAJETEMxgolO95yNYHcCbU6lZFw-FuHMHL0xG3Pyxhy9MccYFz8l7_5u8OnT2YwReH8GoFgIywzR-vLICc6EkGL-NOm4ftx7zKZYj9Gi8xltNS75_3fyAI9dsnQ</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Schell, Lawrence M.</creator><creator>Gallo, Mia V.</creator><creator>Ravenscroft, Julia</creator><creator>DeCaprio, Anthony P.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7TV</scope><scope>7U2</scope><scope>C1K</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20090101</creationdate><title>Persistent organic pollutants and anti-thyroid peroxidase levels in Akwesasne Mohawk young adults</title><author>Schell, Lawrence M. ; Gallo, Mia V. ; Ravenscroft, Julia ; DeCaprio, Anthony P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-9d0f15c2656e6dd62bddba1a372a95d1a2ed0ca43343585868b1c29768d15ee63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Anti-thyroid peroxidase</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Environmental Exposure - adverse effects</topic><topic>Environmental Exposure - analysis</topic><topic>Environmental Pollutants - blood</topic><topic>Environmental Pollutants - toxicity</topic><topic>Environmental pollutants toxicology</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Hydrocarbons, Chlorinated - blood</topic><topic>Hydrocarbons, Chlorinated - toxicity</topic><topic>Indians, North American</topic><topic>Iodide Peroxidase - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Native American</topic><topic>New York</topic><topic>PCBs</topic><topic>Thyroid Hormones - blood</topic><topic>Toxicology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schell, Lawrence M.</creatorcontrib><creatorcontrib>Gallo, Mia V.</creatorcontrib><creatorcontrib>Ravenscroft, Julia</creatorcontrib><creatorcontrib>DeCaprio, Anthony P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schell, Lawrence M.</au><au>Gallo, Mia V.</au><au>Ravenscroft, Julia</au><au>DeCaprio, Anthony P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistent organic pollutants and anti-thyroid peroxidase levels in Akwesasne Mohawk young adults</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>109</volume><issue>1</issue><spage>86</spage><epage>92</epage><pages>86-92</pages><issn>0013-9351</issn><eissn>1096-0953</eissn><coden>ENVRAL</coden><abstract>Persistent organic pollutants, such as polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), and
p,
p′
-dichlorophenyldichloroethylene (DDE), have been found to elicit a broad spectrum of biologic, metabolic, and immunologic responses. The potential of these pollutants to impair immune responses and trigger autoimmune disease is of growing concern, given their structural similarity to thyroid hormones and their potential to modulate the mechanisms and interfere with the binding of these hormones. We examine the relationship of different groupings of PCBs, according to chlorination and structure, and of
p,
p′-DDE and HCB to anti-thyroid peroxidase antibody, a useful tool in the evaluation of thyroid dysfunction, among 115 young adults of the Akwesasne Mohawk Nation.
Overall, 18 participants (15.4%) had anti-thyroid peroxidase antibodies (TPOAb) levels above the normal laboratory reference range (23% of females, 9% of males). Among participants who were breast fed (
n=47), those with an elevated TPOAb level had significantly higher levels of all PCB groupings, with the exception of levels of non-persistent PCBs which did not differ significantly. Levels of
p,
p′-DDE were also significantly elevated, while HCB and mirex were not higher among those with elevated TPOAb. Also, after stratifying by breast-feeding status, participants who were breast fed showed significant, positive relationships between TPOAb levels and all PCB groupings, except groups comprised of non-persistent PCBs, and with
p,
p′-DDE, HCB, and mirex. No effects were evident among non-breast-fed young adults.
Further studies are necessary to elucidate the site and mechanism of action of these persistent organic pollutants (POPs) and to establish thresholds for these effects, especially among populations with background levels of toxicant exposure.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>18995849</pmid><doi>10.1016/j.envres.2008.08.015</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Anti-thyroid peroxidase Autoantibodies - blood Biological and medical sciences Environmental Exposure - adverse effects Environmental Exposure - analysis Environmental Pollutants - blood Environmental Pollutants - toxicity Environmental pollutants toxicology Female General aspects Humans Hydrocarbons, Chlorinated - blood Hydrocarbons, Chlorinated - toxicity Indians, North American Iodide Peroxidase - immunology Male Medical sciences Native American New York PCBs Thyroid Hormones - blood Toxicology Young Adult |
title | Persistent organic pollutants and anti-thyroid peroxidase levels in Akwesasne Mohawk young adults |
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