Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study
Objective: To examine the effect of an intensive lifestyle weight loss intervention (ILI) compared to diabetes support and education (DSE) on changes in fitness and physical activity in the Look AHEAD trial. Design: Randomized clinical trial to compare a lifestyle intervention for weight loss with a...
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| Veröffentlicht in: | International Journal of Obesity 2009-03, Vol.33 (3), p.305-316 |
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| creator | Jakicic, J M Jaramillo, S A Balasubramanyam, A Bancroft, B Curtis, J M Mathews, A Pereira, M Regensteiner, J G Ribisl, P M |
| description | Objective:
To examine the effect of an intensive lifestyle weight loss intervention (ILI) compared to diabetes support and education (DSE) on changes in fitness and physical activity in the Look AHEAD trial.
Design:
Randomized clinical trial to compare a lifestyle intervention for weight loss with a DSE condition in individuals with type 2 diabetes.
Subjects:
Data from 4376 overweight or obese adults with type 2 diabetes (age=58.7±6.8 years, body mass index (BMI)=35.8±5.8 kg/m
2
) who completed 1 year of the Look AHEAD trial and had available fitness data were analyzed.
Intervention:
Subjects were randomly assigned to DSE or ILI. DSE received standard care plus three education sessions over the 1-year period. ILI included individual and group contact throughout the year, restriction in energy intake and 175 min per week of prescribed physical activity.
Measurements:
Fitness was assessed using a submaximal graded exercise test. Physical activity was assessed by questionnaire in a subset of 2221 subjects.
Results:
Change in fitness was statistically greater in ILI vs DSE after adjustment for baseline fitness (20.9 vs 5.7%;
P |
| doi_str_mv | 10.1038/ijo.2008.280 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2656590</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A196305866</galeid><sourcerecordid>A196305866</sourcerecordid><originalsourceid>FETCH-LOGICAL-c576t-b86fccf380621deabe5ad061dcd0a34b7d634d4a6dd93a0ffeedc3b2b2de02f83</originalsourceid><addsrcrecordid>eNptkkuP0zAUhSMEYsrAjjWyQMCGFj9qJ2GBVA2FQarEAlhbjh-NSxp3bGdQfwN_mhtazUzRKJEi-Xz3WPfkFMVzgmcEs-q934QZxbia0Qo_KCZkXoopn9flw2KCGS6nmAt-VjxJaYMx5hzTx8UZqQlnvKKT4s_SOaszCg4p1HlnU953Fvk-23ht--xDj-DVrerX4zHSKhofok07H1UOcY-cz71NaRSVGbqc0G-fW5T3O4soMl41Ntv0AcHMP9XFsEW5tWgVwi-0uFwuPqHveTD7p8Ujp7pknx2_58XPz8sfF5fT1bcvXy8Wq6nmpcjTphJOa8cqLCgxFuy5MlgQow1WbN6URrC5mSthTM0Uhv2s0ayhDTUWU1ex8-LjwXc3NFvQYM2oOrmLfqviXgbl5anS-1auw7WkArKsMRi8PRrEcDVAZHLrk7Zdp3obhiRLxhgloiRAvvyP3IQh9rCdpKSmZc3rGqBXB2itOit97wLcqkdLuSC1YJhXQgA1u4eCx9it16G3zsP5ycCbOwOtVV1uU-iG8Z-mU_DdAdQxpBStu4mCYDl2TELH5NgxCR0D_MXd-G7hY6kAeH0EVNKqc1H12qcbjhJSsxJz4KYHLoEE9Yq34dx78V8f_eow</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219279599</pqid></control><display><type>article</type><title>Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Nature Journals Online</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Jakicic, J M ; Jaramillo, S A ; Balasubramanyam, A ; Bancroft, B ; Curtis, J M ; Mathews, A ; Pereira, M ; Regensteiner, J G ; Ribisl, P M</creator><creatorcontrib>Jakicic, J M ; Jaramillo, S A ; Balasubramanyam, A ; Bancroft, B ; Curtis, J M ; Mathews, A ; Pereira, M ; Regensteiner, J G ; Ribisl, P M ; Look AHEAD Study Group</creatorcontrib><description>Objective:
To examine the effect of an intensive lifestyle weight loss intervention (ILI) compared to diabetes support and education (DSE) on changes in fitness and physical activity in the Look AHEAD trial.
Design:
Randomized clinical trial to compare a lifestyle intervention for weight loss with a DSE condition in individuals with type 2 diabetes.
Subjects:
Data from 4376 overweight or obese adults with type 2 diabetes (age=58.7±6.8 years, body mass index (BMI)=35.8±5.8 kg/m
2
) who completed 1 year of the Look AHEAD trial and had available fitness data were analyzed.
Intervention:
Subjects were randomly assigned to DSE or ILI. DSE received standard care plus three education sessions over the 1-year period. ILI included individual and group contact throughout the year, restriction in energy intake and 175 min per week of prescribed physical activity.
Measurements:
Fitness was assessed using a submaximal graded exercise test. Physical activity was assessed by questionnaire in a subset of 2221 subjects.
Results:
Change in fitness was statistically greater in ILI vs DSE after adjustment for baseline fitness (20.9 vs 5.7%;
P
<0.0001). Multivariate analysis showed that change in fitness was greater in overweight vs obese Class II and III (
P
<0.05). Physical activity increased by 892±1694 kcal per week in ILI vs 108±1254 kcal per week in DSE (
P
<0.01). Changes in fitness (
r
=0.41) and physical activity (
r
=0.42) were significantly correlated with weight loss (
P
<0.0001).
Conclusions:
The ILI was effective in increasing physical activity and improving cardiorespiratory fitness in overweight and obese individuals with type 2 diabetes. This effect may add to weight loss in improving metabolic control in patients in lifestyle intervention programs.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/ijo.2008.280</identifier><identifier>PMID: 19153582</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biological and medical sciences ; Body mass index ; Cardiovascular Diseases - physiopathology ; Cardiovascular Diseases - prevention & control ; Clinical trials ; Control ; Diabetes ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes Mellitus, Type 2 - therapy ; Diabetes. Impaired glucose tolerance ; Diabetic Angiopathies - physiopathology ; Diabetic Angiopathies - prevention & control ; Education ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Epidemiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Exercise ; Exercise - physiology ; Exercise Test ; Female ; Health aspects ; Health Promotion and Disease Prevention ; Humans ; Internal Medicine ; Intervention ; Life Style ; Lifestyles ; Male ; Medical examination ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Multivariate Analysis ; Obesity ; Obesity - complications ; Obesity - physiopathology ; Obesity - therapy ; original-article ; Overweight ; Overweight persons ; Physical Fitness ; Physiological aspects ; Public Health ; Risk factors ; Risk Reduction Behavior ; Surveys and Questionnaires ; Type 2 diabetes ; Weight control ; Weight Loss - physiology</subject><ispartof>International Journal of Obesity, 2009-03, Vol.33 (3), p.305-316</ispartof><rights>Macmillan Publishers Limited 2009</rights><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2009 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c576t-b86fccf380621deabe5ad061dcd0a34b7d634d4a6dd93a0ffeedc3b2b2de02f83</citedby><cites>FETCH-LOGICAL-c576t-b86fccf380621deabe5ad061dcd0a34b7d634d4a6dd93a0ffeedc3b2b2de02f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ijo.2008.280$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ijo.2008.280$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21193705$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19153582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jakicic, J M</creatorcontrib><creatorcontrib>Jaramillo, S A</creatorcontrib><creatorcontrib>Balasubramanyam, A</creatorcontrib><creatorcontrib>Bancroft, B</creatorcontrib><creatorcontrib>Curtis, J M</creatorcontrib><creatorcontrib>Mathews, A</creatorcontrib><creatorcontrib>Pereira, M</creatorcontrib><creatorcontrib>Regensteiner, J G</creatorcontrib><creatorcontrib>Ribisl, P M</creatorcontrib><creatorcontrib>Look AHEAD Study Group</creatorcontrib><title>Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Objective:
To examine the effect of an intensive lifestyle weight loss intervention (ILI) compared to diabetes support and education (DSE) on changes in fitness and physical activity in the Look AHEAD trial.
Design:
Randomized clinical trial to compare a lifestyle intervention for weight loss with a DSE condition in individuals with type 2 diabetes.
Subjects:
Data from 4376 overweight or obese adults with type 2 diabetes (age=58.7±6.8 years, body mass index (BMI)=35.8±5.8 kg/m
2
) who completed 1 year of the Look AHEAD trial and had available fitness data were analyzed.
Intervention:
Subjects were randomly assigned to DSE or ILI. DSE received standard care plus three education sessions over the 1-year period. ILI included individual and group contact throughout the year, restriction in energy intake and 175 min per week of prescribed physical activity.
Measurements:
Fitness was assessed using a submaximal graded exercise test. Physical activity was assessed by questionnaire in a subset of 2221 subjects.
Results:
Change in fitness was statistically greater in ILI vs DSE after adjustment for baseline fitness (20.9 vs 5.7%;
P
<0.0001). Multivariate analysis showed that change in fitness was greater in overweight vs obese Class II and III (
P
<0.05). Physical activity increased by 892±1694 kcal per week in ILI vs 108±1254 kcal per week in DSE (
P
<0.01). Changes in fitness (
r
=0.41) and physical activity (
r
=0.42) were significantly correlated with weight loss (
P
<0.0001).
Conclusions:
The ILI was effective in increasing physical activity and improving cardiorespiratory fitness in overweight and obese individuals with type 2 diabetes. This effect may add to weight loss in improving metabolic control in patients in lifestyle intervention programs.</description><subject>Biological and medical sciences</subject><subject>Body mass index</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Clinical trials</subject><subject>Control</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes Mellitus, Type 2 - therapy</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Angiopathies - physiopathology</subject><subject>Diabetic Angiopathies - prevention & control</subject><subject>Education</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Epidemiology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Intervention</subject><subject>Life Style</subject><subject>Lifestyles</subject><subject>Male</subject><subject>Medical examination</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - physiopathology</subject><subject>Obesity - therapy</subject><subject>original-article</subject><subject>Overweight</subject><subject>Overweight persons</subject><subject>Physical Fitness</subject><subject>Physiological aspects</subject><subject>Public Health</subject><subject>Risk factors</subject><subject>Risk Reduction Behavior</subject><subject>Surveys and Questionnaires</subject><subject>Type 2 diabetes</subject><subject>Weight control</subject><subject>Weight Loss - physiology</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkkuP0zAUhSMEYsrAjjWyQMCGFj9qJ2GBVA2FQarEAlhbjh-NSxp3bGdQfwN_mhtazUzRKJEi-Xz3WPfkFMVzgmcEs-q934QZxbia0Qo_KCZkXoopn9flw2KCGS6nmAt-VjxJaYMx5hzTx8UZqQlnvKKT4s_SOaszCg4p1HlnU953Fvk-23ht--xDj-DVrerX4zHSKhofok07H1UOcY-cz71NaRSVGbqc0G-fW5T3O4soMl41Ntv0AcHMP9XFsEW5tWgVwi-0uFwuPqHveTD7p8Ujp7pknx2_58XPz8sfF5fT1bcvXy8Wq6nmpcjTphJOa8cqLCgxFuy5MlgQow1WbN6URrC5mSthTM0Uhv2s0ayhDTUWU1ex8-LjwXc3NFvQYM2oOrmLfqviXgbl5anS-1auw7WkArKsMRi8PRrEcDVAZHLrk7Zdp3obhiRLxhgloiRAvvyP3IQh9rCdpKSmZc3rGqBXB2itOit97wLcqkdLuSC1YJhXQgA1u4eCx9it16G3zsP5ycCbOwOtVV1uU-iG8Z-mU_DdAdQxpBStu4mCYDl2TELH5NgxCR0D_MXd-G7hY6kAeH0EVNKqc1H12qcbjhJSsxJz4KYHLoEE9Yq34dx78V8f_eow</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Jakicic, J M</creator><creator>Jaramillo, S A</creator><creator>Balasubramanyam, A</creator><creator>Bancroft, B</creator><creator>Curtis, J M</creator><creator>Mathews, A</creator><creator>Pereira, M</creator><creator>Regensteiner, J G</creator><creator>Ribisl, P M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090301</creationdate><title>Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study</title><author>Jakicic, J M ; Jaramillo, S A ; Balasubramanyam, A ; Bancroft, B ; Curtis, J M ; Mathews, A ; Pereira, M ; Regensteiner, J G ; Ribisl, P M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c576t-b86fccf380621deabe5ad061dcd0a34b7d634d4a6dd93a0ffeedc3b2b2de02f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Body mass index</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Clinical trials</topic><topic>Control</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes Mellitus, Type 2 - therapy</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic Angiopathies - physiopathology</topic><topic>Diabetic Angiopathies - prevention & control</topic><topic>Education</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Epidemiology</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Health aspects</topic><topic>Health Promotion and Disease Prevention</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Intervention</topic><topic>Life Style</topic><topic>Lifestyles</topic><topic>Male</topic><topic>Medical examination</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - physiopathology</topic><topic>Obesity - therapy</topic><topic>original-article</topic><topic>Overweight</topic><topic>Overweight persons</topic><topic>Physical Fitness</topic><topic>Physiological aspects</topic><topic>Public Health</topic><topic>Risk factors</topic><topic>Risk Reduction Behavior</topic><topic>Surveys and Questionnaires</topic><topic>Type 2 diabetes</topic><topic>Weight control</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jakicic, J M</creatorcontrib><creatorcontrib>Jaramillo, S A</creatorcontrib><creatorcontrib>Balasubramanyam, A</creatorcontrib><creatorcontrib>Bancroft, B</creatorcontrib><creatorcontrib>Curtis, J M</creatorcontrib><creatorcontrib>Mathews, A</creatorcontrib><creatorcontrib>Pereira, M</creatorcontrib><creatorcontrib>Regensteiner, J G</creatorcontrib><creatorcontrib>Ribisl, P M</creatorcontrib><creatorcontrib>Look AHEAD Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jakicic, J M</au><au>Jaramillo, S A</au><au>Balasubramanyam, A</au><au>Bancroft, B</au><au>Curtis, J M</au><au>Mathews, A</au><au>Pereira, M</au><au>Regensteiner, J G</au><au>Ribisl, P M</au><aucorp>Look AHEAD Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>33</volume><issue>3</issue><spage>305</spage><epage>316</epage><pages>305-316</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>Objective:
To examine the effect of an intensive lifestyle weight loss intervention (ILI) compared to diabetes support and education (DSE) on changes in fitness and physical activity in the Look AHEAD trial.
Design:
Randomized clinical trial to compare a lifestyle intervention for weight loss with a DSE condition in individuals with type 2 diabetes.
Subjects:
Data from 4376 overweight or obese adults with type 2 diabetes (age=58.7±6.8 years, body mass index (BMI)=35.8±5.8 kg/m
2
) who completed 1 year of the Look AHEAD trial and had available fitness data were analyzed.
Intervention:
Subjects were randomly assigned to DSE or ILI. DSE received standard care plus three education sessions over the 1-year period. ILI included individual and group contact throughout the year, restriction in energy intake and 175 min per week of prescribed physical activity.
Measurements:
Fitness was assessed using a submaximal graded exercise test. Physical activity was assessed by questionnaire in a subset of 2221 subjects.
Results:
Change in fitness was statistically greater in ILI vs DSE after adjustment for baseline fitness (20.9 vs 5.7%;
P
<0.0001). Multivariate analysis showed that change in fitness was greater in overweight vs obese Class II and III (
P
<0.05). Physical activity increased by 892±1694 kcal per week in ILI vs 108±1254 kcal per week in DSE (
P
<0.01). Changes in fitness (
r
=0.41) and physical activity (
r
=0.42) were significantly correlated with weight loss (
P
<0.0001).
Conclusions:
The ILI was effective in increasing physical activity and improving cardiorespiratory fitness in overweight and obese individuals with type 2 diabetes. This effect may add to weight loss in improving metabolic control in patients in lifestyle intervention programs.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19153582</pmid><doi>10.1038/ijo.2008.280</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2009-03, Vol.33 (3), p.305-316 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2656590 |
| source | MEDLINE; SpringerLink Journals; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological and medical sciences Body mass index Cardiovascular Diseases - physiopathology Cardiovascular Diseases - prevention & control Clinical trials Control Diabetes Diabetes Mellitus, Type 2 - physiopathology Diabetes Mellitus, Type 2 - therapy Diabetes. Impaired glucose tolerance Diabetic Angiopathies - physiopathology Diabetic Angiopathies - prevention & control Education Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Exercise Exercise - physiology Exercise Test Female Health aspects Health Promotion and Disease Prevention Humans Internal Medicine Intervention Life Style Lifestyles Male Medical examination Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Multivariate Analysis Obesity Obesity - complications Obesity - physiopathology Obesity - therapy original-article Overweight Overweight persons Physical Fitness Physiological aspects Public Health Risk factors Risk Reduction Behavior Surveys and Questionnaires Type 2 diabetes Weight control Weight Loss - physiology |
| title | Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T06%3A52%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20a%20lifestyle%20intervention%20on%20change%20in%20cardiorespiratory%20fitness%20in%20adults%20with%20type%202%20diabetes:%20results%20from%20the%20Look%20AHEAD%20Study&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Jakicic,%20J%20M&rft.aucorp=Look%20AHEAD%20Study%20Group&rft.date=2009-03-01&rft.volume=33&rft.issue=3&rft.spage=305&rft.epage=316&rft.pages=305-316&rft.issn=0307-0565&rft.eissn=1476-5497&rft.coden=IJOBDP&rft_id=info:doi/10.1038/ijo.2008.280&rft_dat=%3Cgale_pubme%3EA196305866%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=219279599&rft_id=info:pmid/19153582&rft_galeid=A196305866&rfr_iscdi=true |